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New Apoptosis Study Findings Recently Were Reported by Researchers at University of Tehran (In vitro antitumor evaluation of...

July 16, 2014



New Apoptosis Study Findings Recently Were Reported by Researchers at University of Tehran (In vitro antitumor evaluation of 4H-chromene-3-carbonitrile derivatives as a new series of apoptotic inducers)

By a News Reporter-Staff News Editor at Biotech Week -- Current study results on Apoptosis have been published. According to news reporting from Tehran, Iran, by NewsRx journalists, research stated, "Apoptosis is a naturally occurring process by which a cell is directed to programmed cell death. Chemotherapy drugs affect the cancer cells by the apoptotic induction."

The news correspondents obtained a quote from the research from the University of Tehran, "During the present study, a series of 4H-chromene-3-carbonitrile was synthesized by one-pot method as the inducers of apoptosis. Cytotoxic effects of six compounds of 4H-chromene-3-carbonitrile were evaluated against five tumor cell lines, with the help of colorimetric 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) assay. Compound 4 showed significant cytotoxic activity and was selected for conjugation with the synthesized gold nanoparticles by aspartic acid. Also, we evaluated apoptosis induction capacity of the selected compound with the help of fluorescent dyes and DNA fragmentation. The result showed that the conjugated and non-conjugated forms of compound 4 were effective in inducing apoptosis and conjugated one had more efficiency and reduced the effective dose."

According to the news reporters, the research concluded: "Also, molecular modeling experiments involving compound 4 and colchicine binding site of tubulin dimer showed several strong hydrogen bonds and hydrophobic interactions to many important amino acid residues and GTP."

For more information on this research see: In vitro antitumor evaluation of 4H-chromene-3-carbonitrile derivatives as a new series of apoptotic inducers. Tumor Biology, 2014;35(6):5845-5855. Tumor Biology can be contacted at: Springer, Van Godewijckstraat 30, 3311 Gz Dordrecht, Netherlands. (Springer - www.springer.com; Tumor Biology - www.springerlink.com/content/1010-4283/)

Our news journalists report that additional information may be obtained by contacting Z. Saffari, Univ Tehran Med Sci, Pharmaceut Sci Res Center, Tehran, Iran. Additional authors for this research include H. Aryapour, A. Akbarzadeh, A. Foroumadi, N. Jafari, M.F. Zarabi and A. Farhangi (see also Apoptosis).

Keywords for this news article include: Iran, Asia, Tehran, Apoptosis

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC


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Source: Biotech Week


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