News Column

New Antibiotics Findings from Nanjing University Discussed (Pyrazole derivatives as antitumor, anti-inflammatory and antibacterial agents)

July 18, 2014

By a News Reporter-Staff News Editor at Drug Week -- New research on Drugs and Therapies is the subject of a report. According to news reporting from Nanjing, People's Republic of China, by NewsRx journalists, research stated, "Within the past years, many researches on the synthesis, structure-activity relationships (SAR), antitumor, antiinflammatory and anti-bacterial activities of the pyrazole derivatives have been reported. Several pyrazole derivatives possess important pharmacological activities and they have been proved useful materials in drug research."

The news correspondents obtained a quote from the research from Nanjing University, "Pyrazole derivatives play an important role in antitumor agents because of their good inhibitory activity against BRAF(V600E), EGFR, telomerase, ROS Receptor Tyrosine Kinase and Aurora-A kinase. In addition, pyrazole derivatives also show good antiinflammatory and anti-bacterial activities. In this review, the bioactivities of the pyrazole derivatives mentioned above will be summarized in detail."

According to the news reporters, the research concluded: "We sincerely hope that increasing knowledge of the SAR and cellular processes underlying the bioactivity of pyrazole derivatives will be beneficial to the rational design of new generation of small molecule drugs."

For more information on this research see: Pyrazole derivatives as antitumor, anti-inflammatory and antibacterial agents. Mini Reviews In Medicinal Chemistry, 2013;13(13):1957-66 (see also Drugs and Therapies).

Our news journalists report that additional information may be obtained by contacting J.J. Liu, State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing 210093, People's Republic of China. Additional authors for this research include M.Y. Zhao, X. Zhang, X. Zhao and H.L Zhu.

Keywords for this news article include: Asia, Antibacterial, Antibiotics, Antimicrobials, Kinase, Nanjing, Drugs and Therapies, Enzymes and Coenzymes, People's Republic of China.

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Source: Drug Week

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