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Investigators from Jilin University Have Reported New Data on Cancer Gene Therapy (Selective expression of tumor necrosis factor-related...

July 14, 2014



Investigators from Jilin University Have Reported New Data on Cancer Gene Therapy (Selective expression of tumor necrosis factor-related apoptosis-inducing ligand mediated by microRNA suppresses renal carcinoma growth)

By a News Reporter-Staff News Editor at Cancer Gene Therapy Week -- Fresh data on Biotechnology are presented in a new report. According to news reporting originating in Changchun, People's Republic of China, by NewsRx journalists, research stated, "Renal cell carcinoma (RCC) is the most common types among kidney cancers. Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) strongly induces apoptosis in RCC."

The news reporters obtained a quote from the research from Jilin University, "However, TRAIL therapy also leads to hepatotoxicity. To improve the biosafety, we inserted miRNA response elements (MREs) of miR-138, miR-199, and miR-122 into an adenoviral vector, Ad-TRAIL-3MREs, to restrict TRAIL expression within RCC cells. Luciferase assays showed that MREs can regulate the expression of exogenous gene in RCC cells. Ad-TRAIL-3MREs selectively expressed TRAIL and induce apoptosis in RCC cells, but not in normal cells. MTT assays revealed that Ad-TRAIL-3MREs reduced viability of RCC cells without cytotoxicity to normal cells. Ad-TRAIL-3MREs suppressed the growth of ACHN tumors and exerted no hepatotoxicity in vivo. Collectively, we generated a TRAIL-expressing adenoviral vector under the regulation of MREs."

According to the news reporters, the research concluded: "This miRNA-based gene therapy may be a promising strategy for RCC treatment."

For more information on this research see: Selective expression of tumor necrosis factor-related apoptosis-inducing ligand mediated by microRNA suppresses renal carcinoma growth. Molecular and Cellular Biochemistry, 2014;392(1-2):125-134. Molecular and Cellular Biochemistry can be contacted at: Springer, Van Godewijckstraat 30, 3311 Gz Dordrecht, Netherlands. (Springer - www.springer.com; Molecular and Cellular Biochemistry - www.springerlink.com/content/0300-8177/)

Our news correspondents report that additional information may be obtained by contacting Z. Zhang, Jilin University, Dept. of Urol, China Japan Union Hosp, Changchun 130033, People's Republic of China. Additional authors for this research include H.Y. Zhang, H.Y. Li, X.L. Chen, M.H. Liu, D.Y. Liu, Y.Y. Zhao and X.B. Kong (see also Biotechnology).

Keywords for this news article include: Asia, Biotechnology, Kidney, Oncology, Changchun, Apoptosis, Cytokines, Nephrology, Renal Cancer, Renal Carcinoma, Cancer Gene Therapy, Renal Cell Carcinoma, Tumor Necrosis Factors, People's Republic of China, Intercellular Signaling Peptides and Proteins

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC


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Source: Cancer Gene Therapy Week


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