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Investigators at Integral University Have Reported New Data on Bone Research (Glycation-assisted synthesized gold nanoparticles inhibit growth of...

July 15, 2014



Investigators at Integral University Have Reported New Data on Bone Research (Glycation-assisted synthesized gold nanoparticles inhibit growth of bone cancer cells)

By a News Reporter-Staff News Editor at Cancer Weekly -- Data detailed on Bone Research have been presented. According to news reporting from Uttar Pradesh, India, by NewsRx journalists, research stated, "This study presents a novel approach to synthesize glycogenic gold nanoparticles (glycogenic GNps) capped with glycated products (Schiff's base, Heyns products, fructosylamine etc.). These glycogenic GNps have been found to be active against human osteosarcoma cell line (Saos-2) with an IC50 of 0.187 mM, while the normal human embryonic lung cell line (L-132) remained unaffected up to 1mM concentration."

The news correspondents obtained a quote from the research from Integral University, "The size of glycogenic GNps can also be controlled by varying the time of incubation of gold solution. Glycation reactions involving a combination of fructose and HSA (Human Serum Albumin) were found to be effective in the reduction of gold to glycogenic GNps whereas glucose in combination with HSA did not result in the reduction of gold. The progress of the reaction was followed using UV-visible spectroscopy and NBT (Nitroblue tetrazolium) assay. The glycogenic GNps were found to be spherical in shape with an average size of 24.3 nm, in a stable emulsion."

According to the news reporters, the research concluded: "These GNps were characterized using UV-visible spectroscopy, zeta potential analysis, transmission electron microscopy (TEM) and scanning electron microscopy (SEM)."

For more information on this research see: Glycation-assisted synthesized gold nanoparticles inhibit growth of bone cancer cells. Colloids and Surfaces B, Biointerfaces, 2014;117():473-9 (see also Bone Research).

Our news journalists report that additional information may be obtained by contacting M. Rahim, Nanomedicine & Nanobiotechnology Lab, Dept. of Biosciences, Integral University, Lucknow, Uttar Pradesh 226026, India. Additional authors for this research include S. Iram, M.S. Khan, M.S. Khan, A.R. Shukla, A.K. Srivastava and S. Ahmad.

Keywords for this news article include: Asia, India, Cancer, Oncology, Nanoparticle, Uttar Pradesh, Bone Research, Nanotechnology, Emerging Technologies.

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC


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Source: Cancer Weekly


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