Findings from Victoria University Update Knowledge of Neurotoxins [Spectroscopic Identification of Neurotoxin Tetramethylenedisulfotetramine (TETS) Captured by Supramolecular Receptor beta-Cyclodextrin Immobilized on Nanostructured Gold Surfaces]
By a News Reporter-Staff News Editor at Health & Medicine Week -- Researchers detail new data in Neurotoxins. According to news reporting originating in Lower Hutt, New Zealand, by NewsRx journalists, research stated, "We report on the spectroscopic identification of tetramethylenedisulfotetramine (TETS), a deadly neurotoxic rodenticide, captured on plasmonic substrates using supramolecular guest-host functionality. Commercial nanopatterned surface-enhanced Raman spectroscopy (SERS) active substrates were self-assembled with host beta-cyclodextrin (CD) and the captured TETS was readily identified by X-ray photoelectron (XPS) and infrared spectroscopy, but not with Raman."
The news reporters obtained a quote from the research from Victoria University, "Density functional theory (DFT) calculation was carried out to determine the Raman scattering cross section of TETS to gauge its Raman scattering efficiency in the preresonant 633 nm excitation region. This was found to be lower than 10(-29) cm(2)/sr, much lower than that of a dye molecule commonly used in SERS experiment. We explain the nondetection of TETS by Raman based on a combined intrinsically weak Raman scattering cross section and their low surface concentration, where XPS only shows a surface coverage of less than 0.02 monolayer with respect to the total number of gold sites."
According to the news reporters, the research concluded: "Comparing this to our own CD-decorated 10 nm gold nanoparticles (NPs) surface, we found that the inherently greater surface area provided by the NPs increases the amount of CD present (per unit area), giving our surface the capability to detect both the receptor and TETS via attenuated total reflectance (ATR) FTIR."
For more information on this research see: Spectroscopic Identification of Neurotoxin Tetramethylenedisulfotetramine (TETS) Captured by Supramolecular Receptor beta-Cyclodextrin Immobilized on Nanostructured Gold Surfaces. Journal of Nanomaterials, 2014;():1-11. Journal of Nanomaterials can be contacted at: Hindawi Publishing Corporation, 410 Park Avenue, 15TH Floor, #287 Pmb, New York, NY 10022, USA. (Hindawi Publishing - www.hindawi.com; Journal of Nanomaterials - www.hindawi.com/journals/jnm/)
Our news correspondents report that additional information may be obtained by contacting H. Dernaika, Victoria University, Robinson Res Inst, Lower Hutt 5046, New Zealand. Additional authors for this research include S.V. Chong, C.G. Artur and J.L. Tallon (see also Neurotoxins).
Keywords for this news article include: Lower Hutt, Neurotoxins, Nanotechnology, Supramolecular, Emerging Technologies, Australia and New Zealand
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