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Findings from University of Madras Has Provided New Information about Carcinomas [Curcumin loaded poly (lactic-co-glycolic) acid nanofiber for the...

July 14, 2014

Findings from University of Madras Has Provided New Information about Carcinomas [Curcumin loaded poly (lactic-co-glycolic) acid nanofiber for the treatment of carcinoma]

By a News Reporter-Staff News Editor at Clinical Oncology Week -- New research on Oncology is the subject of a report. According to news reporting originating from Chennai, India, by NewsRx correspondents, research stated, "Poly (DL-lactic-co-glycolic) acid [PLGA] copolymers with different ratios (78/22, 68/32 and 61/39) and molecular weight (15,400, 11,000 and 10,000 Da) were synthesized and characterized by (1)H NMR, FTIR, GPC and TGA-DTA studies. Curcumin loaded PLGA with the size of 100-300 nm were obtained by electrospinning in which no visible aggregation observed on the surface."

Our news editors obtained a quote from the research from the University of Madras, "The diameter of CPNF (61/39) nanofiber obtained from the topographical imaging by AFM is 16010 nm. The water contact angle measurements indicate that an increase in GA content results in increase in the hydrophilicity of the PLGA copolymer. The in vitro release profile and release kinetics from the CPNF demonstrated a sustained release of curcumin from CPNF. The release profile follows Korsmeyer-Peppas model suggesting a combination of surface drug dissolution and non-Fickian diffusion as a major drug release mechanism."

According to the news editors, the research concluded: "The effect of CPNF on cell viability was assessed by the MTT (3-[4,5-dimethylthiazol-2-yl] 2,5-diphenyltetrazolium bromide) assay to examine the cytotoxic effect of released curcumin on A431 cells in vitro."

For more information on this research see: Curcumin loaded poly (lactic-co-glycolic) acid nanofiber for the treatment of carcinoma. Colloids and Surfaces B, Biointerfaces, 2014;117():128-34 (see also Oncology).

The news editors report that additional information may be obtained by contacting M. Sampath, Dept. of Inorganic Chemistry, University of Madras, Guindy Campus, Chennai 600 025, India. Additional authors for this research include R. Lakra, P. Korrapati and B. Sengottuvelan.

Keywords for this news article include: Asia, India, Chennai, Alkanes, Curcumin, Oncology, Carcinoma, Catechols, Hydrocarbons, Diarylheptanoids, Organic Chemicals.

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Source: Clinical Oncology Week

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