News Column

Findings from University Hospital Update Knowledge of Parkinson's Disease (Retina Measurements For Diagnosis Of Parkinson Disease)

July 14, 2014

By a News Reporter-Staff News Editor at Pain & Central Nervous System Week -- Investigators publish new report on Parkinson's disease. According to news originating from Zaragoza, Spain, by NewsRx correspondents, research stated, "To test the diagnostic ability of spectral domain optical coherence tomography for the detection of Parkinson disease using retinal nerve fiber layer and retinal thickness parameters. Retinal pigment epithelium produces levodopa."

Our news journalists obtained a quote from the research from University Hospital, "Patients with Parkinson disease (n = 111) and healthy subjects (n = 200) were enrolled. The Spectralis optical coherence tomography was used to obtain retinal nerve fiber layer thickness and retinal measurements. Two linear discriminant functions (LDFs) were developed, one using retinal nerve fiber layer parameters and another using retinal thickness. A validating set was used to test the performance of both LDFs. Receiver operating characteristic curves were plotted and compared with the standard parameters provided by optical coherence tomography for both LDFs. Sensitivity and specificity were used to evaluate diagnostic performance. The Retinal LDF combines only retinal thickness parameters and provided the best performance: 31.173 + 0.026 x temporal outer - 0.267 x superior outer + 0.159 x nasal outer - 0.197 x inferior outer - 0.060 x superior inner + 0.049 x foveal thickness. The largest areas under the receiver operating characteristic curve were 0.902 for Retinal LDF. The Retinal LDF yielded the highest sensitivity values."

According to the news editors, the research concluded: "Measurements of retinal thickness differentiate between subjects who are healthy and those with advanced Parkinson disease."

For more information on this research see: Retina Measurements For Diagnosis Of Parkinson Disease. Retina-The Journal of Retinal and Vitreous Diseases, 2014;34(5):971-980. Retina-The Journal of Retinal and Vitreous Diseases can be contacted at: Lippincott Williams & Wilkins, 530 Walnut St, Philadelphia, PA 19106-3621, USA (see also Parkinson's Disease).

The news correspondents report that additional information may be obtained from E. Garcia-Martin, Miguel Servet University Hospital, Dept. of Neurol, Zaragoza, Spain. Additional authors for this research include M. Satue, S. Otin, I. Fuertes, R. Alarcia, J.M. Larrosa, V. Polo and L.E. Pablo.

Keywords for this news article include: Spain, Europe, Zaragoza, Brain Diseases, Imaging Technology, Movement Disorders, Parkinson's Disease, Basal Ganglia Diseases, Parkinsonian Disorders, Neurodegenerative Diseases, Optical Coherence Tomography, Central Nervous System Diseases

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Source: Pain & Central Nervous System Week

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