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Findings from Technical University Reveals New Findings on Drug Development (Interceptor effect of C-60 fullerene on the in vitro action of aromatic...

July 16, 2014

Findings from Technical University Reveals New Findings on Drug Development (Interceptor effect of C-60 fullerene on the in vitro action of aromatic drug molecules)

By a News Reporter-Staff News Editor at Biotech Week -- Researchers detail new data in Drug Development. According to news reporting out of Ilmenau, Germany, by NewsRx editors, research stated, "C-60 fullerenes are spherical molecules composed purely of carbon atoms. They inspire a particularly strong scientific interest because of their specific physico-chemical properties and potential medical and nanotechnological applications."

Our news journalists obtained a quote from the research from Technical University, "In this work we are focusing on studying the influence of the pristine C-60 fullerene on biological activity of some aromatic drug molecules in human buccal epithelial cells. Assessment of the heterochromatin structure in the cell nucleus as well as the barrier function of the cell membrane was performed. The methods of cell microelectrophoresis and atomic force microscopy were also applied. A concentration-dependent restoration of the functional activity of the cellular nucleus after exposure to DNA-binding drugs (doxorubicin, proflavine and ethidium bromide) has been observed in human buccal epithelial cells upon addition of C-60 fullerene at a concentration of similar to 10(-5) M. The results were shown to follow the framework of interceptor/protector action theory, assuming that non-covalent complexation between C-60 fullerene and the drugs (i.e., hetero-association) is the major process responsible for the observed biological effects. An independent confirmation of this hypothesis was obtained via investigation of the cellular response of buccal epithelium to the coadministration of the aromatic drugs and caffeine, and it is based on the well-established role of hetero-association in drug-caffeine systems."

According to the news editors, the research concluded: "The results indicate that C-60 fullerene may reverse the effects caused by the aromatic drugs, thereby pointing out the potential possibility of the use of aromatic drugs in combination with C-60 fullerene for regulation of their medico-biological action."

For more information on this research see: Interceptor effect of C-60 fullerene on the in vitro action of aromatic drug molecules. European Biophysics Journal with Biophysics Letters, 2014;43(6-7):265-276. European Biophysics Journal with Biophysics Letters can be contacted at: Springer, 233 Spring St, New York, NY 10013, USA (see also Drug Development).

Our news journalists report that additional information may be obtained by contacting G.B. Skamrova, Technical University of Ilmenau, Inst Chem & Biotechnol, D-98693 Ilmenau, Germany. Additional authors for this research include I. Laponogov, A.S. Buchelnikov, Y.G. Shckorbatov, S.V. Prylutska, U. Ritter, Y.I. Prylutskyy and M.P. Evstigneev.

Keywords for this news article include: Europe, Carbon, Ilmenau, Germany, Therapy, Fullerenes, Nanotechnology, Drug Development, Emerging Technologies

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC

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Source: Biotech Week

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