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Findings from Singapore National University Provides New Data on Carbamazepine Therapy [Response surface modeling of Carbamazepine (CBZ) removal by...

July 16, 2014



Findings from Singapore National University Provides New Data on Carbamazepine Therapy [Response surface modeling of Carbamazepine (CBZ) removal by Graphene-P25 nanocomposites/UVA process using central composite design]

By a News Reporter-Staff News Editor at Biotech Week -- Current study results on Drugs and Therapies have been published. According to news originating from Singapore, Singapore, by NewsRx correspondents, research stated, "Graphene-P25 (Gr-P25) nanocomposites were synthesized by a simple microwave hydrothermal method. The nanocomposites with different graphene loading were evaluated for the degradation of an important pharmaceutical water pollutant, Carbamazepine (CBZ) under UVA irradiation in a batch reactor."

Our news journalists obtained a quote from the research from Singapore National University, "Response surface methodology (RSM) was used to optimize three key independent operating parameters, namely Gr-P25 nanocomposites dose (X-1), CBZ initial concentration (X-2) and UV light intensity (X-3), for photocatalytic degradation of CBZ. The central composite design (CCD) consisting of 20 experiments determined by 23 full factorial designs with six axial points and six center points was used to conduct experiments. The results showed that CBZ removal was significantly affected by the synergistic effect of linear term of Gr-P25 dose (Xi) and UV intensity (X3). However, the quadratic terms of Gr-P25 (4) and UV intensity (4) had an antagonistic effect on CBZ removal. The obtained RSM model (R-2 = 0.9206) showed a satisfactory correlation between experimental and predicted values of CBZ removal."

According to the news editors, the research concluded: "The optimized conditions for achieving 100% CBZ removal with 5 min UVA irradiation were 25.14 mg/L, 167.68 ppb and 1.35 mW/ cm(2) for Gr-P25 dose, initial concentration of CBZ and UV intensity, respectively."

For more information on this research see: Response surface modeling of Carbamazepine (CBZ) removal by Graphene-P25 nanocomposites/UVA process using central composite design. Water Research, 2014;57():270-279. Water Research can be contacted at: Pergamon-Elsevier Science Ltd, The Boulevard, Langford Lane, Kidlington, Oxford OX5 1GB, England. (Elsevier - www.elsevier.com; Water Research - www.elsevier.com/wps/product/cws_home/309)

The news correspondents report that additional information may be obtained from I.A. Appavoo, Singapore National University, Dept. of Chem, Singapore 117543, Singapore. Additional authors for this research include J.Y. Hu, Y. Huang, S.F.Y. Li and S.L. Ong (see also Drugs and Therapies).

Keywords for this news article include: Asia, Pharmaceuticals, Carbamazepine, Nanocomposite, Nanotechnology, Drugs and Therapies, Emerging Technologies, Central Nervous System Agents, Dibenzazepine Anticonvulsants

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC


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Source: Biotech Week


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