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Findings from Sichuan University in Bone Research Provides New Insights (Deregulation of bone forming cells in bone diseases and anabolic effects of...

July 16, 2014



Findings from Sichuan University in Bone Research Provides New Insights (Deregulation of bone forming cells in bone diseases and anabolic effects of strontium-containing agents and biomaterials)

By a News Reporter-Staff News Editor at Biotech Week -- New research on Bone Research is the subject of a report. According to news originating from Chengdu, People's Republic of China, by NewsRx correspondents, research stated, "Age-related bone loss and osteoporosis are associated with bone remodeling changes that are featured with decreased trabecular and periosteal bone formation relative to bone resorption. Current anticatabolic therapies focusing on the inhibition of bone resorption may not be sufficient in the prevention or reversal of age-related bone deterioration and there is a big need in promoting osteoblastogenesis and bone formation."

Our news journalists obtained a quote from the research from Sichuan University, "Enhanced understanding of the network formed by key signaling pathways and molecules regulating bone forming cells in health and diseases has therefore become highly significant. The successful development of agonist/antagonist of the PTH and Wnt signaling pathways are profits of the understanding of these key pathways. As the core component of an approved antiosteoporosis agent, strontium takes its effect on osteoblasts at multilevel through multiple pathways, representing a good example in revealing and exploring anabolic mechanisms. The recognition of strontium effects on bone has led to its expected application in a variety of biomaterial scaffolds used in tissue engineering strategies aiming at bone repairing and regeneration."

According to the news editors, the research concluded: "While summarizing the recent progress in these respects, this review also proposes the new approaches such as systems biology in order to reveal new insights in the pathology of osteoporosis as well as possible discovery of new therapies."

For more information on this research see: Deregulation of bone forming cells in bone diseases and anabolic effects of strontium-containing agents and biomaterials. Biomed Research International, 2014;2014():814057 (see also Bone Research).

The news correspondents report that additional information may be obtained from S. Tan, Key State Laboratory for Biotherapy, Sichuan University, Chengdu 610065, People's Republic of China. Additional authors for this research include B. Zhang, X. Zhu, P. Ao, H. Guo, W. Yi and G.Q Zhou.

Keywords for this news article include: Asia, Tissue Engineering, Chengdu, Strontium, Bone Research, Alkaline Earth Metals, People's Republic of China.

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC


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Source: Biotech Week


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