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Findings from Northwestern University Reveals New Findings on Tissue Engineering (New strategies in kidney regeneration and tissue engineering)

July 16, 2014

By a News Reporter-Staff News Editor at Biotech Week -- Current study results on Tissue Engineering have been published. According to news reporting originating in Evanston, Illinois, by NewsRx journalists, research stated, "The severe shortage of suitable donor kidneys limits organ transplantation to a small fraction of patients suffering from end-stage renal failure. Engineering autologous kidney grafts on-demand would potentially alleviate this shortage, thereby reducing healthcare costs, improving quality of life, and increasing longevity for patients suffering from renal failure."

The news reporters obtained a quote from the research from Northwestern University, "Over the past 2 years, several studies have demonstrated that structurally intact extracellular matrix (ECM) scaffolds can be derived from human or animal kidneys through decellularization, a process in which detergent or enzyme solutions are perfused through the renal vasculature to remove the native cells. The future clinical paradigm would be to repopulate these decellularized kidney matrices with patient-derived renal stem cells to regenerate a functional kidney graft. Recent research aiming toward this goal has focused on the optimization of decellularization protocols, design of bioreactor systems to seed cells into appropriate compartments of the renal ECM to nurture their growth to restore kidney function, and differentiation of pluripotent stem cells (PSCs) into renal progenitor lineages."

According to the news reporters, the research concluded: "New research efforts utilizing bio-mimetic perfusion bioreactor systems to repopulate decellularized kidney scaffolds, coupled with the differentiation of PSCs into renal progenitor cell populations, indicate substantial progress toward the ultimate goal of building a functional kidney graft on-demand."

For more information on this research see: New strategies in kidney regeneration and tissue engineering. Current Opinion in Nephrology and Hypertension, 2014;23(4):399-405. Current Opinion in Nephrology and Hypertension can be contacted at: Lippincott Williams & Wilkins, 530 Walnut St, Philadelphia, PA 19106-3621, USA. (Lippincott Williams and Wilkins -; Current Opinion in Nephrology and Hypertension -

Our news correspondents report that additional information may be obtained by contacting J.S. Uzarski, Northwestern University, Dept. of Biomed Engn, Evanston, IL 60208, United States. Additional authors for this research include Y. Xia, J.C.I. Belmonte and J.A. Wertheim (see also Tissue Engineering).

Keywords for this news article include: Tissue Engineering, Evanston, Illinois, United States, North and Central America

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Source: Biotech Week

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