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Findings from Hunan University Provides New Data about Drug Delivery Systems (DNA Nanoflowers for Multiplexed Cellular Imaging and Traceable Targeted...

July 16, 2014



Findings from Hunan University Provides New Data about Drug Delivery Systems (DNA Nanoflowers for Multiplexed Cellular Imaging and Traceable Targeted Drug Delivery)

By a News Reporter-Staff News Editor at Biotech Week -- Investigators publish new report on Drugs and Therapies. According to news reporting out of Changsha, People's Republic of China, by NewsRx editors, research stated, "We present a facile approach to make aptamer-conjugated FRET (fluorescent resonance energy transfer) nanoflowers (NFs) through rolling circle replication for multiplexed cellular imaging and traceable targeted drug delivery. The NFs can exhibit multi-fluorescence emissions by a single-wavelength excitation as a result of the DNA matrix covalently incorporated with three dye molecules able to perform FRET."

Our news journalists obtained a quote from the research from Hunan University, "Compared with the conventional DNA nanostructure assembly, NF assembly is independent of template sequences, avoiding the otherwise complicated design of DNA building blocks assembled into nanostructures by base-pairing. The NFs were uniform and exhibited high fluorescence intensity and excellent photostability."

According to the news editors, the research concluded: "Combined with the ability of traceable targeted drug delivery, these colorful DNA NFs provide a novel system for applications in multiplex fluorescent cellular imaging, effective screening of drugs, and therapeutic protocol development."

For more information on this research see: DNA Nanoflowers for Multiplexed Cellular Imaging and Traceable Targeted Drug Delivery. Angewandte Chemie-International Edition, 2014;53(23):5821-5826. Angewandte Chemie-International Edition can be contacted at: Wiley-V C H Verlag Gmbh, Boschstrasse 12, D-69469 Weinheim, Germany (see also Drugs and Therapies).

Our news journalists report that additional information may be obtained by contacting R. Hu, Hunan Univ, Coll Chem & Chem Engn, Collaborat Res Center Chem & Mol Med, Changsha 410082, Hunan, People's Republic of China. Additional authors for this research include X.B. Zhang, Z.L. Zhao, G.Z. Zhu, T. Chen, T. Fu and W.H. Tan.

Keywords for this news article include: Asia, Changsha, DNA Research, Drugs and Therapies, Drug Delivery Systems, People's Republic of China

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC


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Source: Biotech Week


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