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Findings from C. Ferte et al in Bioinformatics Reported (Impact of bioinformatic procedures in the development and translation of high-throughput...

July 14, 2014



Findings from C. Ferte et al in Bioinformatics Reported (Impact of bioinformatic procedures in the development and translation of high-throughput molecular classifiers in oncology)

By a News Reporter-Staff News Editor at Clinical Oncology Week -- Research findings on Biotechnology are discussed in a new report. According to news reporting from Seattle, Washington, by NewsRx journalists, research stated, "The progressive introduction of high-throughput molecular techniques in the clinic allows for the extensive and systematic exploration of multiple biologic layers of tumors. Molecular profiles and classifiers generated from these assays represent the foundation of what the National Academy describes as the future of 'precision medicine'."

The news correspondents obtained a quote from the research, "However, the analysis of such complex data requires the implementation of sophisticated bioinformatic and statistical procedures. It is critical that oncology practitioners be aware of the advantages and limitations of the methods used to generate classifiers to usher them into the clinic. This article uses publicly available expression data from patients with non-small cell lung cancer to first illustrate the challenges of experimental design and preprocessing of data before clinical application and highlights the challenges of high-dimensional statistical analysis."

According to the news reporters, the research concluded: "It provides a roadmap for the translation of such classifiers to clinical practice and makes key recommendations for good practice."

For more information on this research see: Impact of bioinformatic procedures in the development and translation of high-throughput molecular classifiers in oncology. Clinical Cancer Research, 2013;19(16):4315-25. Clinical Cancer Research can be contacted at: Amer Assoc Cancer Research, 615 Chestnut St, 17TH Floor, Philadelphia, PA 19106-4404, USA. (American Association for Cancer Research - www.aacr.com; Clinical Cancer Research - clincancerres.aacrjournals.org/)

Our news journalists report that additional information may be obtained by contacting C. Ferte, Sage Bionetworks, Seattle, WA 98109, United States. Additional authors for this research include A.D. Trister, E. Huang, B.M. Bot, J. Guinney, F. Commo, S. Sieberts, F. Andre, B. Besse, J.C. Soria and S.H Friend (see also Biotechnology).

Publisher contact information for the journal Clinical Cancer Research is: Amer Assoc Cancer Research, 615 Chestnut St, 17TH Floor, Philadelphia, PA 19106-4404, USA.

Keywords for this news article include: Biotechnology, Seattle, Oncology, Washington, United States, Bioengineering, Applied Bioinformatics, North and Central America.

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC


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Source: Clinical Oncology Week


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