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Findings from B.S. Gruben and Colleagues Provides New Insights into Aspergillus (Aspergillus niger RhaR, a regulator involved in lrhamnose release...

July 16, 2014



Findings from B.S. Gruben and Colleagues Provides New Insights into Aspergillus (Aspergillus niger RhaR, a regulator involved in lrhamnose release and catabolism)

By a News Reporter-Staff News Editor at Biotech Week -- Fresh data on Aspergillus are presented in a new report. According to news reporting originating in Zeist, Netherlands, by NewsRx journalists, research stated, "The genome of the filamentous fungus Aspergillus niger is rich in genes encoding pectinases, a broad class of enzymes that have been extensively studied due to their use in industrial applications. The sequencing of the A. niger genome provided more knowledge concerning the individual pectinolytic genes, but little is known about the regulatory genes involved in pectin degradation."

The news reporters obtained a quote from the research, "Understanding regulation of the pectinolytic genes provides a tool to optimize the production of pectinases in this industrially important fungus. This study describes the identification and characterization of one of the activators of pectinase-encoding genes, RhaR. Inactivation of the gene encoding this regulator resulted in down-regulation of genes involved in the release of l-rhamnose from the pectin substructure rhamnogalacturonan I, as well as catabolism of this monosaccharide. The rhaR disruptant was unable to grow on l-rhamnose, but only a small reduction in growth on pectin was observed."

According to the news reporters, the research concluded: "This is likely caused by the presence of a second, so far unknown regulator that responds to the presence of d-galacturonic acid."

For more information on this research see: Aspergillus niger RhaR, a regulator involved in lrhamnose release and catabolism. Applied Microbiology and Biotechnology, 2014;98(12):5531-5540. Applied Microbiology and Biotechnology can be contacted at: Springer, 233 Spring St, New York, NY 10013, USA. (Springer - www.springer.com; Applied Microbiology and Biotechnology - www.springerlink.com/content/0175-7598/)

Our news correspondents report that additional information may be obtained by contacting B.S. Gruben, TNO Microbiol & Syst Biol, Zeist, Netherlands. Additional authors for this research include M.M. Zhou, A. Wiebenga, J. Ballering, K.M. Overkamp, P.J. Punt and R.P. de Vries (see also Aspergillus).

Keywords for this news article include: Zeist, Europe, Genetics, Netherlands, Aspergillus

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC


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Source: Biotech Week


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