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Data on Chemotherapy Reported by Researchers at Southern Medical University (Preparation of novel curcumin-loaded multifunctional nanodroplets for...

July 16, 2014



Data on Chemotherapy Reported by Researchers at Southern Medical University (Preparation of novel curcumin-loaded multifunctional nanodroplets for combining ultrasonic development and targeted chemotherapy)

By a News Reporter-Staff News Editor at Biotech Week -- Researchers detail new data in Drugs and Therapies. According to news reporting originating from Guangzhou, People's Republic of China, by NewsRx correspondents, research stated, "Recently, a new class of multifunctional nanodroplets that combine the properties of polymeric drug carriers, ultrasound imaging contrast agents, and enhancers of ultrasound-mediated drug delivery has been developed. We studied the formation mechanism of nanodroplets of a drug and its application in chemotherapy."

Our news editors obtained a quote from the research from Southern Medical University, "Curcumin was loaded in polymeric micelles as a anti-cancer drug using polyethylene glycol block-poly(caprolactone) with encapsulation efficiency of 95.60%. At room temperature, the developed systems comprised perfluorocarbon nanodroplets stabilized by walls comprising biodegradable block copolymers. Upon heating to 37C, the nanodroplets were converted to nano/microbubbles. Under ultrasound, nanobubbles cavitated and collapsed, resulting in release of the encapsulated drug. The percentage release of curcumin-loaded nanodroplets by insonation was 90.95%, showing enhancement compared with the non-ultrasound group. Nanodroplets strongly retained the loaded drugs in vivo yet, under ultrasound-mediated vaporization, they released the drugs, thereby implementing effective targeting into the tumor. The tumor inhibition of the group in which curcumin-loaded nanodroplets were combined with ultrasound was 71.30%, more than that of the group of curcumin-loaded nanodroplets (53.00%). Nanodroplets showed high enhancement of anti-cancer effects under ultrasound. Upon intravenous injection, a long-lasting, strong and selective ultrasound contrast was observed, suggesting their coalescence into larger, highly echogenic microbubbles."

According to the news editors, the research concluded: "These multifunctional nanodroplets, which manifest excellent therapeutic and ultrasound properties, could be promising anti-cancer drug delivery systems."

For more information on this research see: Preparation of novel curcumin-loaded multifunctional nanodroplets for combining ultrasonic development and targeted chemotherapy. International Journal of Pharmaceutics, 2014;466(1-2):314-20. (Elsevier - www.elsevier.com; International Journal of Pharmaceutics - www.elsevier.com/wps/product/cws_home/505513)

The news editors report that additional information may be obtained by contacting G. Ji, Dept. of Pharmaceutical Science, Nanfang Hospital, Southern Medical University, No 1838 Guangzhou Ave, Guangzhou, 510515, People's Republic of China. Additional authors for this research include J. Yang and J. Chen (see also Drugs and Therapies).

Keywords for this news article include: Asia, Cancer, Alkanes, Curcumin, Oncology, Guangzhou, Catechols, Chemotherapy, Hydrocarbons, Diarylheptanoids, Organic Chemicals, Drugs and Therapies, People's Republic of China.

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC


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Source: Biotech Week


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