Investigators at Institute of Engineering and Technology Discuss Findings in Polymer Research (Physiological pH-triggered morphological transition of amphiphilic block copolymer self-assembly)
By a News Reporter-Staff News Editor at Journal of Technology -- Current study results on Polymer Research have been published. According to news reporting originating from Changzhou, People's Republic of China, by VerticalNews correspondents, research stated, "In order to develop polymeric self-assembly with an intelligent morphological transition property under appropriate stimuli, a series of pH-sensitive amphiphilic block copolymers have been prepared via atom transfer radical polymerization (ATRP). Due to the delicately designed macromolecular structure, poly(ethylene glycol)(44)-b-poly(2-diisopropylaminoethyl methacrylate)(15) (PEG(44)-b-PDPA(15)) could form self-assemblies with a controllable morphological transition in response to the physiological pH changes."
Our news editors obtained a quote from the research from the Institute of Engineering and Technology, "As demonstrated by the results of dynamic light scattering (DLS) records and transmission electron microscopy (TEM) micrographs, PEG(44)-b-PDPA(15) could self-assemble into toruloid aggregates arranged by several single micelles at pH 7.4, but the morphology changed into uniform single micelles at pH 6.5. With a further decrease of pH value to 5.5, PEG-b-PDPA became double hydrophilic and could not self-assemble into any nanostructure."
According to the news editors, the research concluded: "Therefore, this block copolymer provides a feasible approach to construct a nanoscale smart self-assembly with adjustable morphologies, which exhibits its potential for biomedical applications with specific physiological pH stimuli, such as intracellular delivery and tumor therapy."
For more information on this research see: Physiological pH-triggered morphological transition of amphiphilic block copolymer self-assembly. Journal of Polymer Research, 2014;21(7):1-8. Journal of Polymer Research can be contacted at: Springer, Van Godewijckstraat 30, 3311 Gz Dordrecht, Netherlands. (Springer - www.springer.com; Journal of Polymer Research - www.springerlink.com/content/1022-9760/)
The news editors report that additional information may be obtained by contacting W. Wu, Changzhou Inst Engn Technol, Changzhou 213164, People's Republic of China. Additional authors for this research include W.G. Wang, S. Li, J.T. Wang, Q.J. Zhang, X.H. Li, X.L. Luo and J.S. Li.
Keywords for this news article include: Asia, Changzhou, Polymer Research, People's Republic of China
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