Study Results from University of Washington in the Area of Biomedical Optics Reported (Mitigating fluorescence spectral overlap in wide-field endoscopic imaging)
By a News Reporter-Staff News Editor at Biotech Week -- Investigators publish new report on Biotechnology. According to news reporting originating from Seattle, Washington, by NewsRx correspondents, research stated, "The number of molecular species suitable for multispectral fluorescence imaging is limited due to the overlap of the emission spectra of indicator fluorophores, e.g., dyes and nanoparticles. To remove fluorophore emission cross-talk in wide-field multispectral fluorescence molecular imaging, we evaluate three different solutions: (1) image stitching, (2) concurrent imaging with cross-talk ratio subtraction algorithm, and (3) frame-sequential imaging."
Our news editors obtained a quote from the research from the University of Washington, "A phantom with fluorophore emission cross-talk is fabricated, and a 1.2-mm ultrathin scanning fiber endoscope (SFE) is used to test and compare these approaches. Results show that fluorophore emission cross-talk could be successfully avoided or significantly reduced. Near term, the concurrent imaging method of wide-field multispectral fluorescence SFE is viable for early stage cancer detection and localization in vivo."
According to the news editors, the research concluded: "Furthermore, a means to enhance exogenous fluorescence target-to-background ratio by the reduction of tissue autofluorescence background is demonstrated."
For more information on this research see: Mitigating fluorescence spectral overlap in wide-field endoscopic imaging. Journal of Biomedical Optics, 2013;18(8):86012 (see also Biotechnology).
The news editors report that additional information may be obtained by contacting C. Yang, University of Washington, Dept. of Bioengineering, Seattle, Washington 98195, United States. Additional authors for this research include V. Hou, L.Y. Nelson and E.J Seibel.
Keywords for this news article include: Biotechnology, Seattle, Washington, United States, North and Central America.
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