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Study Results from University of Texas Broaden Understanding of Pharmacokinetics (Pharmacokinetics, clearance, and biosafety of polyethylene...

August 6, 2014



Study Results from University of Texas Broaden Understanding of Pharmacokinetics (Pharmacokinetics, clearance, and biosafety of polyethylene glycol-coated hollow gold nanospheres)

By a News Reporter-Staff News Editor at Biotech Week -- Investigators discuss new findings in Pharmacokinetics. According to news reporting originating from Houston, Texas, by NewsRx correspondents, research stated, "Gold nanoparticles have attracted enormous interest as potential theranostic agents. However, little is known about the long-term elimination and systemic toxicity of gold nanoparticles in the literature."

Our news editors obtained a quote from the research from the University of Texas, "Hollow gold nanospheres (HAuNS) is a class of photothermal conducting agent that have shown promises in photoacoustic imaging, photothermal ablation therapy, and drug delivery. It's very necessary to make clear the biosafety of HAuNS for its further application. We investigated the cytotoxicity, complement activation, and platelet aggregation of polyethylene glycol (PEG)-coated HAuNS (PEG-HAuNS, average diameter of 63 nm) in vitro and their pharmacokinetics, biodistribution, organ elimination, hematology, clinical chemistry, acute toxicity, and chronic toxicity in mice. PEG-HAuNS did not induce detectable activation of the complement system and did not induce detectable platelet aggregation. The blood half-life of PEG-HAuNS in mice was 8.19 +/- 1.4 hr. The single effective dose of PEG-HAuNS in photothermal ablation therapy was determined to be 12.5 mg/kg. PEG-HAuNS caused no adverse effects after 10 daily intravenous injections over a 2-week period at a dose of 12.5 mg/kg per injection (accumulated dose: 125 mg/kg). Quantitative analysis of the muscle, liver, spleen, and kidney revealed that the levels of Au decreased 45.2%, 28.6%, 41.7%, and 40.8%, respectively, from day 14 to day 90 after the first intravenous injection, indicating that PEG-HAuNS was slowly cleared from these organs in mice."

According to the news editors, the research concluded: "Our data support the use of PEG-HAuNS as a promising photothermal conducting agent."

For more information on this research see: Pharmacokinetics, clearance, and biosafety of polyethylene glycol-coated hollow gold nanospheres. Particle and Fibre Toxicology, 2014;11():1-14. Particle and Fibre Toxicology can be contacted at: Biomed Central Ltd, 236 Grays Inn Rd, Floor 6, London WC1X 8HL, England. (BioMed Central - www.biomedcentral.com/; Particle and Fibre Toxicology - www.particleandfibretoxicology.com)

The news editors report that additional information may be obtained by contacting J. You, Univ Texas MD Anderson Canc Center, Dept. of Vet Med & Surg, Houston, TX 77030, United States. Additional authors for this research include J.L. Zhou, M. Zhou, Y. Liu, J.D. Robertson, D. Liang, C. Van Pelt and C. Li (see also Pharmacokinetics).

Keywords for this news article include: Pharmaceuticals, Texas, Drugs, Houston, Alkenes, Therapy, Polyenes, Angiology, Hydrocarbons, Nanoparticle, United States, Nanotechnology, Pharmacokinetics, Organic Chemicals, Platelet Aggregation, Polyethylene Glycols, Emerging Technologies, North and Central America

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC


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Source: Biotech Week


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