Study Results from University of Leipzig Broaden Understanding of Life Science Research (The ovine cerebral venous system: comparative anatomy, visualization, and implications for translational research)
By a News Reporter-Staff News Editor at Health & Medicine Week -- Fresh data on Life Science Research are presented in a new report. According to news reporting from Leipzig, Germany, by NewsRx journalists, research stated, "Cerebrovascular diseases are significant causes of death and disability in humans. Improvements in diagnostic and therapeutic approaches strongly rely on adequate gyrencephalic, large animal models being demanded for translational research."
The news correspondents obtained a quote from the research from the University of Leipzig, "Ovine stroke models may represent a promising approach but are currently limited by insufficient knowledge regarding the venous system of the cerebral angioarchitecture. The present study was intended to provide a comprehensive anatomical analysis of the intracranial venous system in sheep as a reliable basis for the interpretation of experimental results in such ovine models. We used corrosion casts as well as contrast-enhanced magnetic resonance venography to scrutinize blood drainage from the brain. This combined approach yielded detailed and, to some extent, novel findings. In particular, we provide evidence for chordae Willisii and lateral venous lacunae, and report on connections between the dorsal and ventral sinuses in this species. For the first time, we also describe venous confluences in the deep cerebral venous system and an 'anterior condylar confluent' as seen in humans. This report provides a detailed reference for the interpretation of venous diagnostic imaging findings in sheep, including an assessment of structure detectability by in vivo (imaging) versus ex vivo (corrosion cast) visualization methods."
According to the news reporters, the research concluded: "Moreover, it features a comprehensive interspecies-comparison of the venous cerebral angioarchitecture in man, rodents, canines and sheep as a relevant large animal model species, and describes possible implications for translational cerebrovascular research."
For more information on this research see: The ovine cerebral venous system: comparative anatomy, visualization, and implications for translational research. Plos One, 2014;9(4):e92990. (Public Library of Science - www.plos.org; Plos One - www.plosone.org)
Our news journalists report that additional information may be obtained by contacting A. Hoffmann, Institute of Anatomy, Histology and Embryology, Faculty of Veterinary Medicine, University of Leipzig, Leipzig, Germany. Additional authors for this research include M.H. Stoffel, B. Nitzsche, D. Lobsien, J. Seeger, H. Schneider and J. Boltze (see also Life Science Research).
Keywords for this news article include: Europe, Leipzig, Germany, Life Science Research.
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