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Study Data from Nanjing Medical University Update Knowledge of Glycopeptides (Electrospun vancomycin-loaded coating on titanium implants for the...

August 5, 2014



Study Data from Nanjing Medical University Update Knowledge of Glycopeptides (Electrospun vancomycin-loaded coating on titanium implants for the prevention of implant-associated infections)

By a News Reporter-Staff News Editor at Life Science Weekly -- Data detailed on Peptides have been presented. According to news reporting originating in Jiangsu, People's Republic of China, by NewsRx journalists, research stated, "The objectives of this work were to develop an antibiotic coating on the surface of a titanium plate to determine its antibacterial properties in vitro and in vivo. To prepare vancomycin-coated titanium implants, we adopted the electrospinning nanotechnique."

The news reporters obtained a quote from the research from Nanjing Medical University, "The surface structure of the coating implants was observed using a scanning electron microscope. An elution method and a high-pressure liquid chromatography assay were used to characterize the release behavior of vancomycin from the coating. The antibacterial efficacy and the cytotoxicity of the coated titanium implants on osteoblasts were investigated in vitro. In addition, X-ray, white blood cell count, C-reactive protein, erythrocyte sedimentation rate, and pathological examination were performed to validate its antimicrobial efficacy in vivo. The antibiotic coating released 82.7% (approximately 528.2 mu g) of total vancomycin loading in the coating in vitro. The release behavior of vancomycin from nanofiber coatings exhibited a biphasic release pattern with an initial burst on day 1, followed by a slow and controlled release over 28 days. There was no cytotoxicity observed in vitro for the vancomycin-loaded coating. The vancomycin-coated titanium implants were active in treating implant-associated infection in vivo."

According to the news reporters, the research concluded: "Thus, vancomycin-coated titanium implants may be a promising approach to prevent and treat implant-associated infections."

For more information on this research see: Electrospun vancomycin-loaded coating on titanium implants for the prevention of implant-associated infections. International Journal of Nanomedicine, 2014;9():3027-3036. International Journal of Nanomedicine can be contacted at: Dove Medical Press Ltd, PO Box 300-008, Albany, Auckland 0752, New Zealand (see also Peptides).

Our news correspondents report that additional information may be obtained by contacting L. Zhang, Nanjing Medical University, Nanjing Hosp 1, Orthoped Lab, Nanjing 210006, Jiangsu, People's Republic of China. Additional authors for this research include J.W. Yan, Z.W. Yin, C. Tang, Y. Guo, D. Li, B. Wei, Y. Xu, Q.R. Gu and L.M. Wang.

Keywords for this news article include: Asia, Jiangsu, Titanium, Vancomycin, Light Metals, Glycopeptides, People's Republic of China

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC


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Source: Life Science Weekly


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