Study Data from Kongju National University Provide New Insights into Cysteine Endopeptidases (Identification of novel binding partners for caspase-6 using a proteomic approach)
By a News Reporter-Staff News Editor at Biotech Week -- Research findings on Enzymes and Coenzymes are discussed in a new report. According to news reporting out of Daejeon, South Korea, by NewsRx editors, research stated, "Apoptosis is the process of programmed cell death executed by specific proteases, the caspases, which mediate the cleavage of various vital proteins. Elucidating the consequences of this endoproteolytic cleavage is crucial to understanding cell death and other related biological processes."
Our news journalists obtained a quote from the research from Kongju National University, "Although a number of possible roles for caspase-6 have been proposed, the identities and functions of proteins that interact with caspase-6 remain uncertain. In this study, we established a cell line expressing tandem affinity purification (TAP)-tagged caspase-6 and then used LC-MS/MS proteomic analysis to analyze the caspase-6 interactome. Eight candidate caspase-6-interacting proteins were identified. Of these, five proteins (hnRNP-M, DHX38, ASPP2, MTA2, and UACA) were subsequently examined by co-immunoprecipitation for interactions with caspase-6."
According to the news editors, the research concluded: "Thus, we identified two novel members of the caspase-6 interactome: hnRNP-M and MTA2."
For more information on this research see: Identification of novel binding partners for caspase-6 using a proteomic approach. Journal of Microbiology and Biotechnology, 2014;24(5):714-8 (see also Enzymes and Coenzymes).
Our news journalists report that additional information may be obtained by contacting J.Y. Jung, Medical Proeomics Research Center, Korea Research Institute of Bioscience & Biotechnology, Daejeon 305-333, Republic of Korea, Dept. of Biology, Kongju National University, Kongju 314-701, South Korea. Additional authors for this research include S.R. Lee, S. Kim, S.W. Chi, K.H. Bae, B.C. Park, J.H. Kim and S.G Park.
Keywords for this news article include: Asia, Daejeon, Caspases, Proteomics, South Korea, Peptide Hydrolases, Enzymes and Coenzymes, Cysteine Endopeptidases.
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