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Studies in the Area of Nanoparticles Reported from University of Catania (Influence of different surfactants on the technological properties and in...

August 8, 2014



Studies in the Area of Nanoparticles Reported from University of Catania (Influence of different surfactants on the technological properties and in vivo ocular tolerability of lipid nanoparticles)

By a News Reporter-Staff News Editor at Drug Week -- Investigators publish new report on Nanoparticles. According to news originating from Catania, Italy, by NewsRx correspondents, research stated, "Addition of one or more surfactant agents is often necessary for the production of nanostructured lipid and polymeric systems. The removal of residual surfactants is a required step for technological and toxicological reasons, especially for peculiar applications, such as the ophthalmic field."

Our news journalists obtained a quote from the research from the University of Catania, "This study was planned to assess the technological properties of some surfactants, commonly used for the production of lipid nanoparticles, as well as their ocular safety profile. Stable and small-size solid lipid nanoparticles were obtained using Dynasan 114 as the lipid matrix and all the tested surfactants. However, from a toxicological point of view, the nanocarriers produced using Kolliphor P188 were the most valuable, showing no irritant effect on the ocular surface up to the highest tested surfactant concentration (0.4%, w/v)."

According to the news editors, the research concluded: "The SLN produced using Cremophor A25 and Lipoid S100 were tolerated up to a surfactant concentration of 0.2% by weight, while for Tween 80 and Kolliphor HS 15 a maximum concentration of 0.05% can be considered totally not-irritant."

For more information on this research see: Influence of different surfactants on the technological properties and in vivo ocular tolerability of lipid nanoparticles. International Journal of Pharmaceutics, 2014;470(1-2):133-140. International Journal of Pharmaceutics can be contacted at: Elsevier Science Bv, PO Box 211, 1000 Ae Amsterdam, Netherlands. (Elsevier - www.elsevier.com; International Journal of Pharmaceutics - www.elsevier.com/wps/product/cws_home/505513)

The news correspondents report that additional information may be obtained from A. Leonardi, University of Catania, Res Center Ocular Nanotechnol, NANO i, I-95125 Catania, Italy. Additional authors for this research include C. Bucolo, G.L. Romano, C.B.M. Platania, F. Drago, G. Puglisi and R. Pignatello (see also Nanoparticles).

Keywords for this news article include: Italy, Europe, Catania, Nanotechnology, Emerging Technologies

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC


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Source: Drug Week


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