Studies from Uppsala University in the Area of Bone Research Reported (Novel injectable biomaterials for bone augmentation based on isosorbide dimethacrylic monomers)
By a News Reporter-Staff News Editor at Health & Medicine Week -- Current study results on Bone Research have been published. According to news originating from Uppsala, Sweden, by NewsRx correspondents, research stated, "Drawbacks with the commonly used PMMA-based bone cements, such as an excessive elastic modulus and potentially toxic residual monomer content, motivate the development of alternative cements. In this work an attempt to prepare an injectable biomaterial based on isosorbide-alicyclic diol derived from renewable resources was presented."
Our news journalists obtained a quote from the research from Uppsala University, "Two novel dimethacrylic monomers ISDGMA - 2,5-bis(2-hydroxy-3-methacryloyloxypropoxy)-1,4:3,6-dianhydro-sorbitol and ISETDMA - dimethacrylate of ethoxylated isosorbide were synthesized and used to prepare a series of low-viscosity compositions comprising bioactive nano-sized hydroxyapatite in the form of a two-paste system. Formulations exhibited a non-Newtonian shear-thinning behavior, setting times between 2.6 min and 53 min at 37 degrees C and maximum curing temperatures of 65 degrees C. Due to the hydrophilic nature of ISDGMA, cured compositions could absorb up to 13.6% water and as a result the Young's modulus decreased from 1429 MPa down to 470 MPa. Both, poly(ISDGMA) and poly(ISETDMA) were subjected to a MU study on mice fibroblasts (BALB/3T3) and gave relative cell viabilities above 70% of control. A selected model bone cement was additionally investigated using human osteosarcoma cells (SaOS-2) in an MTS test, which exhibited concentration-dependent cell viability."
According to the news editors, the research concluded: "The preliminary results, presented in this work reveal the potential of two novel dimethacrylic monomers in the preparation of an injectable biomaterial for bone augmentation, which could overcome some of the drawbacks typical for conventional acrylic bone cement."
For more information on this research see: Novel injectable biomaterials for bone augmentation based on isosorbide dimethacrylic monomers. Materials Science & Engineering C-Materials for Biological Applications, 2014;40():76-84. Materials Science & Engineering C-Materials for Biological Applications can be contacted at: Elsevier Science Bv, PO Box 211, 1000 Ae Amsterdam, Netherlands (see also Bone Research).
The news correspondents report that additional information may be obtained from J. Lukaszczyk, Uppsala University, Dept. of Engn Sci, Div Appl Mat Sci, Angstrom Lab, S-75120 Uppsala, Sweden. Additional authors for this research include B. Janicki, A. Lopez, K. Skolucka, H. Wojdyla, C. Persson, S. Piaskowski and M. Smiga-Matuszowicz.
Keywords for this news article include: Sweden, Europe, Uppsala, Sorbitol, Isosorbide, Bone Research
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