Studies from University of Southampton Update Current Data on Biochemistry (Gold nanoparticles explore cells: Cellular uptake and their use as intracellular probes)
By a News Reporter-Staff News Editor at Health & Medicine Week -- Data detailed on Biochemistry have been presented. According to news originating from Southampton, United Kingdom, by NewsRx correspondents, research stated, "Understanding uptake of nanomaterials by cells and their use for intracellular sensing is important for studying their interaction and toxicology as well as for obtaining new biological insight. Here, we investigate cellular uptake and intracellular dynamics of gold nanoparticles and demonstrate their use in reporting chemical information from the endocytotic pathway and cytoplasm."
Our news journalists obtained a quote from the research from the University of Southampton, "The intracellular gold nanoparticles serve as probes for surface-enhanced Raman spectroscopy (SERS) allowing for biochemical characterisation of their local environment. In particular, in this work we compare intracellular SERS using non-functionalised and functionalised nanoparticles in their ability to segregate different but closely related cell phenotypes. The results indicate that functionalised gold nanoparticles are more efficient in distinguishing between different types of cells."
According to the news editors, the research concluded: "Our studies pave the way for understanding the uptake of gold nanoparticles and their utilisation for SERS to give rise to a greater biochemical understanding in cell-based therapies."
For more information on this research see: Gold nanoparticles explore cells: Cellular uptake and their use as intracellular probes. Methods, 2014;68(2):354-363. Methods can be contacted at: Academic Press Inc Elsevier Science, 525 B St, Ste 1900, San Diego, CA 92101-4495, USA. (Elsevier - www.elsevier.com; Methods - www.elsevier.com/wps/product/cws_home/622914)
The news correspondents report that additional information may be obtained from A. Huefner, University of Southampton, Dept. of Chem, Southampton SO17 1BJ, Hants, United Kingdom. Additional authors for this research include D. Septiadi, B.D. Wilts, I.I. Patel, W.L. Kuan, A. Fragniere, R.A. Barker and S. Mahajan (see also Biochemistry).
Keywords for this news article include: Europe, Southampton, Biochemical, Biochemistry, United Kingdom, Nanotechnology, Gold Nanoparticles, Emerging Technologies
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