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Studies from University of California Yield New Information about Genetics and Magnetic Resonance Imaging (Genetically encoded reporters for...

August 8, 2014



Studies from University of California Yield New Information about Genetics and Magnetic Resonance Imaging (Genetically encoded reporters for hyperpolarized xenon magnetic resonance imaging)

By a News Reporter-Staff News Editor at Genomics & Genetics Weekly -- Investigators publish new report on Diagnostic Imaging. According to news reporting originating in Berkeley, California, by NewsRx journalists, research stated, "Magnetic resonance imaging (MRI) enables high-resolution non-invasive observation of the anatomy and function of intact organisms. However, previous MRI reporters of key biological processes tied to gene expression have been limited by the inherently low molecular sensitivity of conventional H-1 MRI."

The news reporters obtained a quote from the research from the University of California, "This limitation could be overcome through the use of hyperpolarized nuclei, such as in the noble gas xenon, but previous reporters acting on such nuclei have been synthetic. Here, we introduce the first genetically encoded reporters for hyperpolarized Xe-129 MRI. These expressible reporters are based on gas vesicles (GVs), gas-binding protein nanostructures expressed by certain buoyant microorganisms. We show that GVs are capable of chemical exchange saturation transfer interactions with xenon, which enables chemically amplified GV detection at picomolar concentrations (a 100- to 10,000-fold improvement over comparable constructs for H-1 MRI)."

According to the news reporters, the research concluded: "We demonstrate the use of GVs as heterologously expressed indicators of gene expression and chemically targeted exogenous labels in MRI experiments performed on living cells."

For more information on this research see: Genetically encoded reporters for hyperpolarized xenon magnetic resonance imaging. Nature Chemistry, 2014;6(7):630-635. Nature Chemistry can be contacted at: Nature Publishing Group, Macmillan Building, 4 Crinan St, London N1 9XW, England. (Nature Publishing Group - www.nature.com/; Nature Chemistry - www.nature.com/nchem/)

Our news correspondents report that additional information may be obtained by contacting M.G. Shapiro, University of California, Dept. of Chem, Berkeley, CA 94720, United States. Additional authors for this research include R.M. Ramirez, L.J. Sperling, G. Sun, J. Sun, A. Pines, D.V. Schaffer and V.S. Bajaj (see also Diagnostic Imaging).

Keywords for this news article include: Xenon, Berkeley, Genetics, California, United States, Diagnostic Imaging, North and Central America, Magnetic Resonance Imaging

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC


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Source: Genomics & Genetics Weekly


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