Studies from University of Akron Further Understanding of Hemolysis (Controlled Lecithin Release from a Hierarchical Architecture on Blood-Contacting Surface to Reduce Hemolysis of Stored Red Blood Cells)
By a News Reporter-Staff News Editor at Health & Medicine Week -- Investigators discuss new findings in Hemolysis. According to news originating from Akron, Ohio, by NewsRx correspondents, research stated, "Hemolysis of red blood cells (RBCs) caused by implant devices in vivo and nonpolyvinyl chloride containers for RBC preservation in vitro has recently gained much attention. To develop blood-contacting biomaterials with long-term antihemolysis capability, we present a facile method to construct a hydrophilic, 3D hierarchical architecture on the surface of styrene-b-(ethylene-co-butylene)-b-styrene elastomer (SEBS) with poly(ethylene oxide) (PEO)/lecithin nano/microfibers."
Our news journalists obtained a quote from the research from the University of Akron, "The strategy is based on electrospinning of PEO/lecithin fibers onto the surface of poly [poly(ethylene glycol) methyl ether methacrylate] [P(PEGMEMA)]-modified SEBS, which renders SEBS suitable for RBC storage in vitro. We demonstrate that the constructed 3D architecture is composed of hydrophilic micro- and nanofibers, which transforms to hydrogel networks immediately in blood; the controlled release of lecithin is achieved by gradual dissolution of PEO/lecithin hydrogels, and the interaction of lecithin with RBCs maintains the membrane flexibility and normal RBC shape. Thus, the blood-contacting surface reduces both mechanical and oxidative damage to RBC membranes, resulting in low hemolysis of preserved RBCs."
According to the news editors, the research concluded: "This work not only paves new way to fabricate high hemocompatible biomaterials for RBC storage in vitro, but provides basic principles to design and develop antihemolysis biomaterials for implantation in vivo."
For more information on this research see: Controlled Lecithin Release from a Hierarchical Architecture on Blood-Contacting Surface to Reduce Hemolysis of Stored Red Blood Cells. ACS Applied Materials & Interfaces, 2014;6(12):9808-9814. ACS Applied Materials & Interfaces can be contacted at: Amer Chemical Soc, 1155 16TH St, NW, Washington, DC 20036, USA. (American Chemical Society - www.acs.org; ACS Applied Materials & Interfaces - www.pubs.acs.org/journal/aamick)
The news correspondents report that additional information may be obtained from Q. Shi, Univ Akron, Dept. of Mech Engn, Akron, OH 44325, United States. Additional authors for this research include Q.F. Fan, W. Ye, J.W. Hou, S.C. Wong, X.D. Xu and J.H. Yin (see also Hemolysis).
Keywords for this news article include: Ohio, Akron, Hemolysis, Blood Cells, United States, North and Central America
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