Studies from National Center for Scientific Research (CNRS) Further Understanding of Essential Amino Acids (Improved gene transfer with histidine-functionalized mesoporous silica nanoparticles)
By a News Reporter-Staff News Editor at Drug Week -- Investigators discuss new findings in Essential Amino Acids. According to news originating from Orleans, France, by NewsRx correspondents, research stated, "Mesoporous silica nanoparticles (MSN) were functionalized with aminopropyltriethoxysilane (MSN-NH2) then L-histidine (MSN-His) for pDNA delivery in cells and in vivo."
Our news journalists obtained a quote from the research from National Center for Scientific Research (CNRS), "The complexation of pDNA with MSN-NH2 and MSN-His was first studied with gel shift assay. pDNA complexed with MSN-His was better protected from DNase degradation than with MSN-NH2. An improvement of the transfection efficiency in cells was observed with MSN-His/pDNA compared to MSN-NH2/pDNA, which could be explained by a better internalization of MSN-His."
According to the news editors, the research concluded: "The improvement of the transfection efficiency with MSN-His was also observed for gene transfer in Achilles tendons in vivo."
For more information on this research see: Improved gene transfer with histidine-functionalized mesoporous silica nanoparticles. International Journal of Pharmaceutics, 2014;471(1-2):197-205. International Journal of Pharmaceutics can be contacted at: Elsevier Science Bv, PO Box 211, 1000 Ae Amsterdam, Netherlands. (Elsevier - www.elsevier.com; International Journal of Pharmaceutics - www.elsevier.com/wps/product/cws_home/505513)
The news correspondents report that additional information may be obtained from D. Brevet, CNRS, Center Biophys Mol, UPR 4301, F-45071 Orleans, France. Additional authors for this research include O. Hocine, A. Delalande, L. Raehm, C. Charnay, P. Midoux, J.O. Durand and C. Pichon (see also Essential Amino Acids).
Keywords for this news article include: France, Europe, Orleans, Histidine, Nanoparticle, Nanotechnology, Cyclic Amino Acids, Emerging Technologies, Essential Amino Acids
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