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Studies from Hong Kong University of Science and Technology Have Provided New Data on Food Science (Determination of Aristolochic Acids by...

August 5, 2014



Studies from Hong Kong University of Science and Technology Have Provided New Data on Food Science (Determination of Aristolochic Acids by High-Performance Liquid Chromatography with Fluorescence Detection)

By a News Reporter-Staff News Editor at Life Science Weekly -- Data detailed on Food Science have been presented. According to news reporting originating from Hong Kong, People's Republic of China, by NewsRx correspondents, research stated, "Nephrotoxic and carcinogenic aristolochic acids (AAs) are naturally occurring nitrophenanthrene carboxylic acids in the herbal genus Aristolochia. The misuse of AA-containing herbs in preparing slimming drugs has caused hundred of cases of kidney disease in Belgium women in a slimming regime in the early 1990s."

Our news editors obtained a quote from the research from the Hong Kong University of Science and Technology, "Accumulating evidence also suggested that prolong dietary intake of AA-contaminated food is one of the major causes to the Balkan endemic nephropathy that was first observed in the late 1950s. Therefore, analytical methods of high sensitivity are extremely important for safeguarding human exposure to AA-containing herbal medicines, herbal remedies, and food composites. In this paper, we describe the development of a new high-performance liquid chromatography coupled fluorescence detector (HPLC-FLD) method for the sensitive determination of AAs. The method makes use of a novel cysteine-induced denitration reaction that 'turns on' the fluorescence of AAs for fluorometric detections. Our results showed that the combination of cysteine-induced denitration and HPLC-FLD analysis allows for sensitive quantification of AA-I and AA-II at detection limits of 27.1 and 25.4 ng/g, respectively."

According to the news editors, the research concluded: "The method was validated and has been successfully applied in quantifying AAs in Chinese herbal medicines."

For more information on this research see: Determination of Aristolochic Acids by High-Performance Liquid Chromatography with Fluorescence Detection. Journal of Agricultural and Food Chemistry, 2014;62(25):5859-5864. Journal of Agricultural and Food Chemistry can be contacted at: Amer Chemical Soc, 1155 16TH St, NW, Washington, DC 20036, USA. (American Chemical Society - www.acs.org; Journal of Agricultural and Food Chemistry - www.pubs.acs.org/journal/jafcau)

The news editors report that additional information may be obtained by contacting Y.A. Wang, Hong Kong University of Science & Technology, Dept. of Chem, Kowloon, Hong Kong, People's Republic of China (see also Food Science).

Keywords for this news article include: Asia, Hong Kong, Food Science, Imaging Technology, People's Republic of China, High-Performance Liquid Chromatography

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC


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Source: Life Science Weekly


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