Studies from Gwangju Institute of Science and Technology (GIST) Describe New Findings in Alzheimer Disease (Antibody-based magnetic nanoparticle immunoassay for quantification of Alzheimer's disease pathogenic factor)
By a News Reporter-Staff News Editor at Health & Medicine Week -- Investigators publish new report on Neurodegenerative Diseases. According to news reporting originating in Kwangju, South Korea, by NewsRx journalists, research stated, "Alzheimer's disease (AD) is a neurodegenerative disorder that leads to a decline in cognitive and intellectual abilities and an irreversible mental deterioration. Based on multidisciplinary AD research, the most universally accepted hypotheses on AD pathogenesis are the intracerebral aggregate formation of beta-amyloid (A beta) peptides."
The news reporters obtained a quote from the research from the Gwangju Institute of Science and Technology (GIST), "According to medical paradigmatic transition from medical treatment to early diagnostic prevention, scientists have considered physiological body fluid as a biomarker medium, in which the promising AD biomarkers could be verified. Recently, use of saliva has been considered as one of the diagnostic fluids over the past decade with meaningful diagnostic potential. We utilized saliva as a biomarker medium to correlate the salivary A beta levels to AD pathological aspects, especially to the mild cognitive impairment group among AD patients, and to verify our detecting system to be sensitive enough for an early diagnostic tool. The identification of the salivary AD biomarkers using a facile microarraying method would motivate this study with the assistance of magnetically assembled antibody-conjugated nanoparticles and a photomultiplier tube as an optical detector. This simple magnetoimmunoassay system measures the photointensity generated by fluorescence, enables the quantification of the A beta peptides from AD salivary samples, and consequently classifies the salivary A beta levels into AD pathological aspects. This method demonstrates a facile approach enabling it to simply detect salivary A beta peptides at a concentration as low as similar to 20 pg/ml."
According to the news reporters, the research concluded: "It is expected that our simple magnetoimmunoassay system may have a potential as a detector for low-level A beta peptides with weak-fluorescence emission."
For more information on this research see: Antibody-based magnetic nanoparticle immunoassay for quantification of Alzheimer's disease pathogenic factor. Journal of Biomedical Optics, 2014;19(5):36-42. Journal of Biomedical Optics can be contacted at: Spie-Soc Photo-Optical Instrumentation Engineers, 1000 20TH St, PO Box 10, Bellingham, WA 98225, USA (see also Neurodegenerative Diseases).
Our news correspondents report that additional information may be obtained by contacting C.B. Kim, Gwangju Inst Sci & Technol, Kwangju 500712, South Korea. Additional authors for this research include Y.Y. Choi, W.K. Song and K.B. Song.
Keywords for this news article include: Asia, Antibodies, Kwangju, Dementia, Immunology, South Korea, Tauopathies, Blood Proteins, Brain Diseases, Nanotechnology, Immunoglobulins, Alzheimer Disease, Emerging Technologies, Magnetic Nanoparticles, Neurodegenerative Diseases, Central Nervous System Diseases
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