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Studies Conducted at Semnan University on Antibiotics Recently Reported (Synthesis, characterisation and antibacterial effects of sol-gel derived...

August 8, 2014



Studies Conducted at Semnan University on Antibiotics Recently Reported (Synthesis, characterisation and antibacterial effects of sol-gel derived biphasic calcium phosphate nanopowders)

By a News Reporter-Staff News Editor at Drug Week -- Research findings on Drugs and Therapies are discussed in a new report. According to news reporting originating from Semnan, Iran, by NewsRx correspondents, research stated, "Hydroxyapatite (HA) and beta-tricalcium phosphate (beta-TCP) represent the main types of calcium phosphates used for the reconstruction of bone defects in maxillofacial, dental, orthopaedic and drug delivery applications. The bioactivity and bioresorbability of biphasic calcium phosphate (BCP) ceramics can be controlled by varying the HA/beta-TCP ratio."

Our news editors obtained a quote from the research from Semnan University, "In this reported work, BCP nanopowders were prepared by a simple sol-gel method, in which Ca(NO3)(2)center dot 4H(2)O and P2O5 were used as precursors for calcium and phosphate, respectively. The different phase ratios of HA/beta-TCP were obtained by changing the sintering temperature. X-ray diffraction, inductive coupled plasma-atomic emission spectroscopy, scanning electron microscopy, transmission electron microscopy and Fourier transformer infrared spectrophotometer results have shown that increasing the sintering temperature could cause more decomposition of HA into beta-TCP. Moreover, the size of the prepared nanoparticles was measured between 10 and 500 nm. Finally, the antibacterial activity was studied using Escherichia coli (ATCC 25922) as the Gram-negative bacteria. The antibacterial effect of the BCP sample with 50% HA-50%beta-TCP phase ratio was tested at concentrations of 100, 200 and 300 mg/ml."

According to the news editors, the research concluded: "The results showed bacterial growth reduction at a concentration of 300 mg/ml, which makes it a good candidate for the treatment of bone defects."

For more information on this research see: Synthesis, characterisation and antibacterial effects of sol-gel derived biphasic calcium phosphate nanopowders. Micro & Nano Letters, 2014;9(6):403-406. Micro & Nano Letters can be contacted at: Inst Engineering Technology-Iet, Michael Faraday House Six Hills Way Stevenage, Hertford SG1 2AY, England (see also Drugs and Therapies).

The news editors report that additional information may be obtained by contacting Z. Nazemi, Semnan Univ, Dept. of Vet Med, Semnan 3513119111, Iran. Additional authors for this research include M.H. Nazarpak, M. Mehdikhani-Nahrkhalaji, H. Staji and M.M. Kalani.

Keywords for this news article include: Iran, Asia, Antibacterial, Antibiotics, Antimicrobials, Semnan, Anions, Nanopowder, Bone Research, Nanotechnology, Phosphoric Acids, Calcium Compounds, Calcium Phosphates, Drugs and Therapies, Inorganic Chemicals, Phosphorus Compounds, Emerging Technologies

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC


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Source: Drug Week


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