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Researchers from University of Modena and Reggio Emilia Report Recent Findings in Cytoplasmic Vesicles (Characterization of lysosome-destabilizing...

August 8, 2014



Researchers from University of Modena and Reggio Emilia Report Recent Findings in Cytoplasmic Vesicles (Characterization of lysosome-destabilizing DOPE/PLGA nanoparticles designed for cytoplasmic drug release)

By a News Reporter-Staff News Editor at Drug Week -- Fresh data on Cytoplasmic Vesicles are presented in a new report. According to news reporting from Modena, Italy, by NewsRx journalists, research stated, "Polymeric nanoparticles (NPs) offer a promising approach for therapeutic intracellular delivery of proteins, conventionally hampered by short half-lives, instability and immunogenicity. Remarkably, NPs uptake occurs via endocytic internalization leading to NPs content's release within lysosomes."

The news correspondents obtained a quote from the research from the University of Modena and Reggio Emilia, "To overcome lysosomal degradation and achieve NPs and/or loaded proteins release into cytosol, we propose the formulation of hybrid NPs by adding 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine (DOPE) as pH sensitive component in the formulation of poly-lactide-co-glycolide (PLGA) NPs. Hybrid NPs, featured by different DOPE/PLGA ratios, were characterized in terms of structure, stability and lipid organization within the polymeric matrix. Experiments on NIH cells and rat primary neuronal cultures highlighted the safety profile of hybrid NPs. Moreover, after internalization, NPs are able to transiently destabilize the integrity of lysosomes in which they are taken up, speeding their escape and favoring cytoplasmatic localization."

According to the news reporters, the research concluded: "Thus, these DOPE/PLGA-NPs configure themselves as promising carriers for intracellular protein delivery."

For more information on this research see: Characterization of lysosome-destabilizing DOPE/PLGA nanoparticles designed for cytoplasmic drug release. International Journal of Pharmaceutics, 2014;471(1-2):349-357. International Journal of Pharmaceutics can be contacted at: Elsevier Science Bv, PO Box 211, 1000 Ae Amsterdam, Netherlands. (Elsevier - www.elsevier.com; International Journal of Pharmaceutics - www.elsevier.com/wps/product/cws_home/505513)

Our news journalists report that additional information may be obtained by contacting R. Chhabra, Univ Modena & Reggio Emilia, Te Far TI Grp, Dept. of Life Sci, Modena, Italy. Additional authors for this research include A.M. Grabrucker, P. Veratti, D. Belletti, T.M. Boeckers, M.A. Vandelli, F. Forni, G. Tosi and B. Ruozi (see also Cytoplasmic Vesicles).

Keywords for this news article include: Italy, Modena, Europe, Lysosomes, Nanoparticle, Nanotechnology, Intracellular Space, Cytoplasmic Vesicles, Emerging Technologies, Cytoplasmic Structures

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC


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Source: Drug Week


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