News Column

Researchers from University of California Describe Findings in Nanoparticles (Precise quantification of nanoparticle internalization)

August 8, 2014

By a News Reporter-Staff News Editor at Health & Medicine Week -- Current study results on Nanoparticles have been published. According to news reporting originating in Santa Barbara, California, by NewsRx journalists, research stated, "Nanoparticles have opened new exciting avenues for both diagnostic and therapeutic applications in human disease, and targeted nanoparticles are increasingly used as specific drug delivery vehicles. The precise quantification of nanoparticle internalization is of importance to measure the impact of physical and chemical properties on the uptake of nanoparticles into target cells or into cells responsible for rapid clearance."

The news reporters obtained a quote from the research from the University of California, "Internalization of nanoparticles has been measured by various techniques, but comparability of data between different laboratories is impeded by lack of a generally accepted standardized assay. Furthermore, the distinction between associated and internalized particles has been a challenge for many years, although this distinction is critical for most research questions. Previously used methods to verify intracellular location are typically not quantitative and do not lend themselves to high-throughput analysis. Here, we developed a mathematical model which integrates the data from high-throughput flow cytometry measurements with data from quantitative confocal microscopy. The generic method described here will be a useful tool in biomedical nanotechnology studies. The method was then applied to measure the impact of surface coatings of vesosomes on their internalization by cells of the reticuloendothelial system (RES). RES cells are responsible for rapid clearance of nanoparticles, and the resulting fast blood clearance is one of the major challenges in biomedical applications of nanoparticles."

According to the news reporters, the research concluded: "Coating of vesosomes with long chain polyethylene glycol showed a trend for lower internalization by RES cells."

For more information on this research see: Precise quantification of nanoparticle internalization. Acs Nano, 2013;7(6):4933-45. (American Chemical Society -; Acs Nano -

Our news correspondents report that additional information may be obtained by contacting C. Gottstein, Dept. of Chemical Engineering and California NanoSystems Institute, University of California-Santa Barbara, Santa Barbara, California 93106-6105, United States. Additional authors for this research include G. Wu, B.J. Wong and J.A Zasadzinski (see also Nanoparticles).

Keywords for this news article include: California, Santa Barbara, United States, Nanotechnology, Emerging Technologies, North and Central America.

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC

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Source: Health & Medicine Week

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