Researchers from University of Applied Sciences Provide Details of New Studies and Findings in the Area of Pharmaceutical Research (Nanocrystals of medium soluble actives-Novel concept for improved dermal delivery and production strategy)
By a News Reporter-Staff News Editor at Biotech Week -- Research findings on Drugs and Therapies are discussed in a new report. According to news reporting from Pirmasens, Germany, by NewsRx journalists, research stated, "After use in oral pharmaceutical products, nanocrystals are meanwhile applied to improve the dermal penetration of cosmetic actives (e.g. rutin, hesperidin) and of drugs. By now, nanocrystals are only dermally applied made from poorly soluble actives."
The news correspondents obtained a quote from the research from the University of Applied Sciences, "The novel concept is to formulate nanocrystals also from medium soluble actives, and to apply a dermal formulation containing additionally nanocrystals. The nanocrystals should act as fast dissolving depot, increase saturation solubility and especially accumulate in the hair follicles, to further increase skin penetration. Caffeine was used as model compound with relevance to market products, and a particular process was developed for the production of caffeine nanocrystals to overcome the supersaturation related effect of crystal growth and fiber formation - typical with medium soluble compounds. It is based on low energy milling (pearl milling) in combination with low dielectric constant dispersion media (water-ethanol or ethanol-propylene glycol mixtures) and optimal stabilizers. Most successful was Carbopol ® 981 (e.g. 20% caffeine in ethanol-propylene glycol 3:7 with 2% Carbopol, w/w). Nanocrystals with varied sizes can now be produced in a controlled process e.g. 660 nm (optimal for hair follicle accumulation) to 250 nm (optimal for fast dissolution)."
According to the news reporters, the research concluded: "The short term test proved stability over 2 months of the present formulation being sufficient to perform in vivo testing of the novel concept."
For more information on this research see: Nanocrystals of medium soluble actives-Novel concept for improved dermal delivery and production strategy. International Journal of Pharmaceutics, 2014;470(1-2):141-150. International Journal of Pharmaceutics can be contacted at: Elsevier Science Bv, PO Box 211, 1000 Ae Amsterdam, Netherlands. (Elsevier - www.elsevier.com; International Journal of Pharmaceutics - www.elsevier.com/wps/product/cws_home/505513)
Our news journalists report that additional information may be obtained by contacting X.Z. Zhai, Univ Appl Sci Kaiserslautern, Fachhsch, D-66953 Pirmasens, Germany. Additional authors for this research include J. Lademann, C.M. Keck and R.H. Muller (see also Drugs and Therapies).
Keywords for this news article include: Europe, Germany, Caffeine, Pirmasens, Anorexigenic Agent, Drugs and Therapies, Phosphodiesterase Inhibitors, Central Nervous System Stimulants
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