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Researchers from University of Adelaide Report on Findings in Cancer Gene Therapy (Endosomal pH responsive polymers for efficient cancer targeted...

August 4, 2014



Researchers from University of Adelaide Report on Findings in Cancer Gene Therapy (Endosomal pH responsive polymers for efficient cancer targeted gene therapy)

By a News Reporter-Staff News Editor at Cancer Gene Therapy Week -- Investigators discuss new findings in Biotechnology. According to news reporting originating from Adelaide, Australia, by NewsRx correspondents, research stated, "Treatment of human diseases at gene level is always limited by effective gene delivery vectors. In this study, we designed and developed an endosomal pH sensitive targeted gene delivery system, folic acid functionalized Schiff-base linked imidazole chitosan (FA-SLICS), for cancer therapy."

Our news editors obtained a quote from the research from the University of Adelaide, "The FA-SLICS is able to self-assemble plasmid DNA (pDNA) into nano-scaled polyplexes under a neutral condition and to release the loaded pDNA in the endosomal microenvironment due to the presence of pH sensitive Schiff-base moieties along chitosan backbones. The FA-SLICS has negligible cytotoxicity to normal cells (CHO), but displays slight toxicity to cancer cells (HeLa and HepG2). In addition, FA-SLICS can selectively and efficiently transfect FR (folate receptor) positive cells (HeLa cells) as a gene carrier."

According to the news editors, the research concluded: "Therefore, the FA-SLICS should be a promising delivery vector in cancer gene therapy based on its cell targeting capability and intracellular microenvironment controlled delivery mechanism."

For more information on this research see: Endosomal pH responsive polymers for efficient cancer targeted gene therapy. Colloids and Surfaces B-Biointerfaces, 2014;119():55-65. Colloids and Surfaces B-Biointerfaces can be contacted at: Elsevier Science Bv, PO Box 211, 1000 Ae Amsterdam, Netherlands (see also Biotechnology).

The news editors report that additional information may be obtained by contacting B.Y. Shi, University of Adelaide, Sch Chem Engn, Adelaide, SA 5005, Australia. Additional authors for this research include H. Zhang, J.X. Bi and S. Dai.

Keywords for this news article include: Biotechnology, Adelaide, Oncology, Bioengineering, Cancer Gene Therapy, Australia and New Zealand

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC


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Source: Cancer Gene Therapy Week


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