Researchers from National Center for Scientific Research (CNRS) Describe Findings in Biosensing (A real time affinity biosensor on an insulated polymer using electric impedance spectroscopy in dielectric microchips)
By a News Reporter-Staff News Editor at Biotech Week -- Current study results on Biosensing have been published. According to news originating from Paris, France, by NewsRx correspondents, research stated, "This paper presents development of real time monitoring of binding events on flexible plastic in microchips. Two planar carbon microelectrodes are integrated into an insulated polyethylene terephthalate microchip without direct electrical contact with the solution in the microchannel."
Our news journalists obtained a quote from the research from National Center for Scientific Research (CNRS), "It has been possible to probe the electric impedance changes through the interface constituted by the microelectrode/PET microchannel/solution when a biomolecular interaction takes place on the polymer surface. This new transduction for biosensing was demonstrated for the molecular recognition of BSA immobilized on the polymer microchannel surface using the corresponding rabbit anti-BSA antibodies as an analyte in the flow microchannel at the nanomolar range concentration. The equilibrium association constant was determined for the affinity reaction between both ligands and was obtained equal to 5 x 10(7) M(-1)."
According to the news editors, the research concluded: "The promising results obtained with this new device make it a competitive biosensor."
For more information on this research see: A real time affinity biosensor on an insulated polymer using electric impedance spectroscopy in dielectric microchips. Analyst, 2014;139(12):3115-21. (Royal Society of Chemistry - www.rsc.org/; Analyst - pubs.rsc.org/en/journals/journalissues/an)
The news correspondents report that additional information may be obtained from M. Kechadi, CNRS, UMR 8235, Laboratoire Interface et Systemes Electrochimiques, (LISE), F-75005 Paris, France. Additional authors for this research include B. Sotta, L. Chaal, B. Tribollet and J. Gamby (see also Biosensing).
Keywords for this news article include: Paris, France, Europe, Biosensing, Bioengineering, Bionanotechnology, Nanobiotechnology.
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