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Researchers from Naresuan University Detail Findings in DNA Research (Recyclable magnetic nanoparticle grafted with pH-responsive polymer for...

August 5, 2014



Researchers from Naresuan University Detail Findings in DNA Research (Recyclable magnetic nanoparticle grafted with pH-responsive polymer for adsorption with DNA)

By a News Reporter-Staff News Editor at Life Science Weekly -- Current study results on DNA Research have been published. According to news reporting out of Phitsanulok, Thailand, by NewsRx editors, research stated, "Magnetite nanoparticles (MNPs) grafted with positively charged poly(2-(diethylamino) ethyl methacrylate (PDEAEMA) were prepared via a combination of atom transfer radical polymerization (ATRP) and 'click' reaction and used as recyclable nanosupports for adsorption with DNA. Alkyne-terminated PDEAEMA was synthesized via ATRP and then 'grafted to' azide-functionalized MNPs."

Our news journalists obtained a quote from the research from Naresuan University, "Quaternized PDEAEMA-grafted MNPs were used as recyclable nanosupports for adsorption with negatively charged DNA via electrostatic interactions. The particles with the size of 3-8 nm in diameter were well dispersible in water. They responded to the change in their solution pH as observed by a consistent decrease in hydrodynamic size when solution pH changed from basic to acidic pH. Recycling efficiency of the MNPs was investigated by determining the percent adsorption of the particles after multiple cycles of the adsorption-separation-desorption process."

According to the news editors, the research concluded: "Adsorption ability of the MNPs to T-9 DNA tagged with fluorescein at 5'-position (FAM-dT(9)) retained higher than 80 % after 5-recycling process, indicating that these novel positively charged MNPs might be efficiently used as magnetic nanosupports for any negative biomolecules with good recycling efficiency."

For more information on this research see: Recyclable magnetic nanoparticle grafted with pH-responsive polymer for adsorption with DNA. Journal of Nanoparticle Research, 2014;16(7):1-12. Journal of Nanoparticle Research can be contacted at: Springer, Van Godewijckstraat 30, 3311 Gz Dordrecht, Netherlands. (Springer - www.springer.com; Journal of Nanoparticle Research - www.springerlink.com/content/1388-0764/)

Our news journalists report that additional information may be obtained by contacting P. Theamdee, Naresuan Univ, Fac Sci, Center Excellence Biomat, Phitsanulok 65000, Thailand. Additional authors for this research include B. Rutnakornpituk, U. Wichai and M. Rutnakornpituk (see also DNA Research).

Keywords for this news article include: Asia, Thailand, Phitsanulok, DNA Research

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC


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Source: Life Science Weekly


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