Researchers at Yale University Describe Findings in Life Science Research (Multi-platform compatible software for analysis of polymer bending mechanics)
By a News Reporter-Staff News Editor at Computer Weekly News -- Research findings on Life Science Research are discussed in a new report. According to news reporting originating from New Haven, Connecticut, by VerticalNews correspondents, research stated, "Cytoskeletal polymers play a fundamental role in the responses of cells to both external and internal stresses. Quantitative knowledge of the mechanical properties of those polymers is essential for developing predictive models of cell mechanics and mechano-sensing."
Our news editors obtained a quote from the research from Yale University, "Linear cytoskeletal polymers, such as actin filaments and microtubules, can grow to cellular length scales at which they behave as semiflexible polymers that undergo thermally-driven shape deformations. Bending deformations are often modeled using the wormlike chain model. A quantitative metric of a polymer's resistance to bending is the persistence length, the fundamental parameter of that model. A polymer's bending persistence length is extracted from its shape as visualized using various imaging techniques. However, the analysis methodologies required for determining the persistence length are often not readily within reach of most biological researchers or educators. Motivated by that limitation, we developed user-friendly, multi-platform compatible software to determine the bending persistence length from images of surface-adsorbed or freely fluctuating polymers. Three different types of analysis are available (cosine correlation, end-to-end and bending-mode analyses), allowing for rigorous cross-checking of analysis results."
According to the news editors, the research concluded: "The software is freely available and we provide sample data of adsorbed and fluctuating filaments and expected analysis results for educational and tutorial purposes."
For more information on this research see: Multi-platform compatible software for analysis of polymer bending mechanics. Plos One, 2014;9(4):e94766. (Public Library of Science - www.plos.org; Plos One - www.plosone.org)
The news editors report that additional information may be obtained by contacting J.S. Graham, Dept. of Molecular Biophysics and Biochemistry, Yale University, New Haven, Connecticut, United States. Additional authors for this research include B.R. McCullough, H. Kang, W.A. Elam, W. Cao and E.M De La Cruz.
Keywords for this news article include: Software, New Haven, Connecticut, United States, Life Science Research, North and Central America.
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