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Researchers at Southwest University for Nationalities Detail Findings in Connective Tissue Cells (Cellular extract facilitates nuclear reprogramming...

August 6, 2014



Researchers at Southwest University for Nationalities Detail Findings in Connective Tissue Cells (Cellular extract facilitates nuclear reprogramming by altering DNA methylation and pluripotency gene expression)

By a News Reporter-Staff News Editor at Biotech Week -- Current study results on Connective Tissue Cells have been published. According to news reporting from Chengdu, People's Republic of China, by NewsRx journalists, research stated, "The functional reprogramming of a differentiated cell to a pluripotent state presents potential beneficial applications in disease mechanisms and regenerative medicine. Epigenetic modifications enable differentiated cells to perpetuate molecular memory to retain their identity."

The news correspondents obtained a quote from the research from Southwest University for Nationalities, "Therefore, the aim of this study was to investigate the reprogramming modification of yak fibroblast cells that were permeabilized and incubated in the extracts of mesenchymal stem cells derived from mice adipose tissue [adipose-derived stem cells (ADSCs)]. According to the results, the treatment of ADSC extracts promoted colony formation. Moreover, pluripotent gene expression was associated with the loss of repressive histone modifications and increased global demethylation. The genes Col1a1 and Col1a2, which are typically found in differentiated cells only, demonstrated decreased expression and increased methylation in the 5'-flanking regulatory regions. Moreover, yak fibroblast cells that were exposed to ADSC extracts resulted in significantly different eight-cell and blastocyst formation rates of cloned embryos compared with their untreated counterparts. This investigation provides the first evidence that nuclear reprogramming of yak fibroblast cells is modified after the ADSC extract treatment."

According to the news reporters, the research concluded: "This research also presents a methodology for studying the dedifferentiation of somatic cells that can potentially lead to an efficient way of reprogramming somatic cells toward a pluripotent state without genetic alteration."

For more information on this research see: Cellular extract facilitates nuclear reprogramming by altering DNA methylation and pluripotency gene expression. Cellular Reprogramming, 2014;16(3):215-22. (Mary Ann Liebert, Inc. - www.liebertpub.com; Cellular Reprogramming - www.liebertpub.com/overview/cellular-reprogramming-formerly-cloning-and-stem-cells/9/)

Our news journalists report that additional information may be obtained by contacting X.R. Xiong, 1 College of Life Science and Technology, Southwest University for Nationalities , Chengdu, Sichuan, 610041, People's Republic of China. Additional authors for this research include D.L. Lan, J. Li, X.D. Zi, L. Ma and Y. Wang (see also Connective Tissue Cells).

Keywords for this news article include: Asia, Chengdu, Fibroblasts, Connective Tissue Cells, People's Republic of China.

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC


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Source: Biotech Week


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