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Researchers at Silpakorn University Target Nanoparticles (Terpene Composited Lipid Nanoparticles for Enhanced Dermal Delivery of All-trans-Retinoic...

August 5, 2014



Researchers at Silpakorn University Target Nanoparticles (Terpene Composited Lipid Nanoparticles for Enhanced Dermal Delivery of All-trans-Retinoic Acids)

By a News Reporter-Staff News Editor at Life Science Weekly -- Investigators publish new report on Nanoparticles. According to news reporting out of Nakorn Panom, Thailand, by NewsRx editors, research stated, "In the present study, terpene composited lipid nanoparticles and lipid nanoparticles were developed and evaluated for dermal delivery of all-trans-retinoic acids (ATRA). Terpene composited lipid nanoparticles and lipid nanoparticles were investigated for size, size distribution, zeta potential, entrapment efficiency, photostability, and cytotoxicity."

Our news journalists obtained a quote from the research from Silpakorn University, "In vitro skin permeation of ATRA lipid formulations were also evaluated. To explore the ability of lipid nanocarriers to target the skin, the distribution of rhodamine B base in the skin was investigated using confocal laser scanning microscopy (CLSM). The results indicated that the physicochemical characteristics of terpene composited lipid nanoparticles influenced skin permeability. All lipid nanocarriers significantly protected ATRA from photodegradation and were non-toxic to normal human foreskin fibroblast cells in vitro. Solid lipid nanoparticles containing 10% limonene (10% L-SLN) had the highest ATRA skin permeability. Terpene composited SLN and nanostructured lipid carriers (NLC) showed higher epidermal permeation of rhodamine B across the skin based on CLSM image analysis."

According to the news editors, the research concluded: "Our study suggests that terpene composited SLN and NLC can be potentially used as dermal drug delivery carriers for ATRA."

For more information on this research see: Terpene Composited Lipid Nanoparticles for Enhanced Dermal Delivery of All-trans-Retinoic Acids. Biological & Pharmaceutical Bulletin, 2014;37(7):1139-1148. Biological & Pharmaceutical Bulletin can be contacted at: Pharmaceutical Soc Japan, 2-12-15 Shibuya, Shibuya-Ku, Tokyo, 150-0002, Japan (see also Nanoparticles).

Our news journalists report that additional information may be obtained by contacting P. Charoenputtakun, Silpakorn University, Fac Pharm, Nakhon Pathom 73000, Thailand. Additional authors for this research include B. Pamornpathomkul, P. Opanasopit, T. Rojanarata and T. Ngawhirunpat.

Keywords for this news article include: Asia, Thailand, Nakorn Panom, Nanotechnology, Emerging Technologies

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC


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Source: Life Science Weekly


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