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Researchers at Research Institute Report New Data on Toll-Like Receptors (Toll-Like Receptor 4 is Involved in Titanium Dioxide Nanoparticle...

August 5, 2014



Researchers at Research Institute Report New Data on Toll-Like Receptors (Toll-Like Receptor 4 is Involved in Titanium Dioxide Nanoparticle Incorporation Into Cells)

By a News Reporter-Staff News Editor at Life Science Weekly -- Current study results on Immunology have been published. According to news reporting originating from Kitakyushu, Japan, by NewsRx correspondents, research stated, "The innate immune system is important for defense against foreign pathogens, such as bacteria and viruses. We hypothesized that the innate immune system is also important for the interaction between cells and nanomaterials, because cells do not have a specific defense system for nanomaterials."

Our news editors obtained a quote from the research from Research Institute, "In this study, we demonstrated the effect of Toll-Like Receptor 4 (TLR 4), which is an important molecule for the innate immune system, on the uptake of TiO2 nanoparticles (NPs). The results indicated that TLR 4 expression vector-transfected cells increased the uptake of TiO2 NPs and also increased IL-6 mRNA induction by TiO2 NP exposure."

According to the news editors, the research concluded: "Modifying TiO2 NPs with polyethylene glycol (PEG) reduced their uptake and inflammatory-signal transduction via TLR 4. Our results suggest that TLR 4 is important for interactions between cells and NPs, and that PEGylation of TiO2 NPs reduces the cellular response via interaction with TLR 4."

For more information on this research see: Toll-Like Receptor 4 is Involved in Titanium Dioxide Nanoparticle Incorporation Into Cells. Science of Advanced Materials, 2014;6(7):1562-1568. Science of Advanced Materials can be contacted at: Amer Scientific Publishers, 26650 The Old Rd, Ste 208, Valencia, CA 91381-0751, USA. (American Scientific Publishers - www.aspbs.com/)

The news editors report that additional information may be obtained by contacting S.S. Mano, TOTO Ltd Res Inst, Kitakyushu, Fukuoka 8028601, Japan. Additional authors for this research include K. Kanehira, S. Sonezaki and A. Taniguchi (see also Immunology).

Keywords for this news article include: Asia, Japan, Chemicals, Chemistry, Kitakyushu, Immunology, Nanomaterial, Nanotechnology, Titanium Dioxide, Membrane Proteins, Toll-Like Receptor 4, Emerging Technologies, Pattern Recognition Receptors

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC


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Source: Life Science Weekly


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