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Researchers at Konkuk University Report New Data on Influenza (An RNA aptamer that specifically binds to the glycosylated hemagglutinin of avian...

August 5, 2014



Researchers at Konkuk University Report New Data on Influenza (An RNA aptamer that specifically binds to the glycosylated hemagglutinin of avian influenza virus and suppresses viral infection in cells)

By a News Reporter-Staff News Editor at Virus Weekly -- Research findings on Influenza are discussed in a new report. According to news reporting originating in Seoul, South Korea, by NewsRx journalists, research stated, "The influenza virus surface glycoprotein hemagglutinin (HA) is responsible for viral attachment to sialic acid-containing host cell receptors and it facilitates the initial stage of viral infection. In the present study, we isolated an RNA aptamer specific to the glycosylated receptor-binding domain of the HA protein (gHA1) after 12 cycles of the systematic evolution of ligands by exponential enrichment procedure (SELEX), and we then investigated if the selected aptamer suppresses viral infection in host cells."

The news reporters obtained a quote from the research from Konkuk University, "Nitrocellulose filter binding and enzyme-linked immunosorbent assay (ELISA) experiments revealed that 1 RNA aptamer, HA12-16, bound specifically to the gHA1 protein. Cell viability assay showed that the HA12-16 RNA aptamer suppressed viral infection in host cells by enhancing cell viability. Immunofluorescence microscopic analysis further demonstrated that the HA12-16 RNA aptamer suppresses viral attachment to host cells by neutralizing the receptor-binding site of influenza virus HA."

According to the news reporters, the research concluded: "These results indicate that the isolated RNA aptamer can be developed as an antiviral reagent against influenza through appropriate therapeutic formulation."

For more information on this research see: An RNA aptamer that specifically binds to the glycosylated hemagglutinin of avian influenza virus and suppresses viral infection in cells. Plos One, 2014;9(5):e97574. (Public Library of Science - www.plos.org; Plos One - www.plosone.org)

Our news correspondents report that additional information may be obtained by contacting H.M. Kwon, Dept. of Bioscience and Biotechnology, Konkuk University, Seoul, South Korea. Additional authors for this research include K.H. Lee, B.W. Han, M.R. Han, D.H. Kim and D.E Kim (see also Influenza).

Keywords for this news article include: Asia, Seoul, Influenza, Viral RNA, South Korea.

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC


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Source: Virus Weekly


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