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Research Data from University of Putra Malaysia Update Understanding of Cancer Therapy (Anticancer nanodelivery system with controlled release...

August 6, 2014



Research Data from University of Putra Malaysia Update Understanding of Cancer Therapy (Anticancer nanodelivery system with controlled release property based on protocatechuate-zinc layered hydroxide nanohybrid)

By a News Reporter-Staff News Editor at Biotech Week -- Research findings on Oncology are discussed in a new report. According to news reporting out of Selangor, Malaysia, by NewsRx editors, research stated, "We characterize a novel nanocomposite that acts as an efficient anticancer agent. This nanocomposite consists of zinc layered hydroxide intercalated with protocatechuate (an anionic form of protocatechuic acid), that has been synthesized using a direct method with zinc oxide and protocatechuic acid as precursors."

Our news journalists obtained a quote from the research from the University of Putra Malaysia, "The resulting protocatechuic acid nanocomposite (PAN) showed a basal spacing of 12.7, indicating that protocatechuate was intercalated in a monolayer arrangement, with an angle of 54 from the Z-axis between the interlayers of the zinc layered hydroxide, and an estimated drug loading of about 35.7%. PAN exhibited the properties of a mesoporous type material, with greatly enhanced thermal stability of protocatechuate as compared to its free counterpart. The presence of protocatechuate in the interlayers of the zinc layered hydroxide was further supported by Fourier transform infrared spectroscopy. Protocatechuate was released from PAN in a slow and sustained manner. This mechanism of release was well represented by a pseudo-second order kinetics model. PAN has shown increased cytotoxicity compared to the free form of protocatechuic acid in all cancer cell lines tested. Tumor growth suppression was extensive, particularly in HepG2 and HT29 cell lines. PAN is suitable for use as a controlled release formulation, and our in vitro evidence indicates that PAN is an effective anticancer agent."

According to the news editors, the research concluded: "PAN may have potential as a chemotherapeutic drug for human cancer."

For more information on this research see: Anticancer nanodelivery system with controlled release property based on protocatechuate-zinc layered hydroxide nanohybrid. International Journal of Nanomedicine, 2014;9():3137-3149. International Journal of Nanomedicine can be contacted at: Dove Medical Press Ltd, PO Box 300-008, Albany, Auckland 0752, New Zealand (see also Oncology).

Our news journalists report that additional information may be obtained by contacting F. Barahuie, University of Putra Malaysia, Dept. of Human Anat, Fac Med & Hlth Sci, Serdang 43400, Selangor, Malaysia. Additional authors for this research include M.Z. Hussein, S.A. Gani, S. Fakurazi and Z. Zainal.

Keywords for this news article include: Asia, Anions, Therapy, Selangor, Malaysia, Alkalies, Oncology, Hydroxides, Controlled Release, Inorganic Chemicals

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC


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Source: Biotech Week


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