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Research Conducted at Pohang University of Science and Technology Has Provided New Information about Peptide Receptors (Aptamer-conjugated gold...

August 5, 2014



Research Conducted at Pohang University of Science and Technology Has Provided New Information about Peptide Receptors (Aptamer-conjugated gold nanorod for photothermal ablation of epidermal growth factor receptor-overexpressed epithelial cancer)

By a News Reporter-Staff News Editor at Cancer Weekly -- Current study results on Membrane Proteins have been published. According to news reporting originating from Pohang, South Korea, by NewsRx correspondents, research stated, "Biomarker-specific photothermal nanoparticles that can efficiently sense markers that are overexpressed in distinguished adenocarcinomas have attracted much interest in an aspect of efficacy increase of cancer treatment. We demonstrated a promising prospect of a smart photothermal therapy agent employing anti-epidermal growth factor receptor aptamer (Apt(EGFR))-conjugated polyethylene glycol (PEG) layted gold nanorods (Apt(EGFR)-PGNRs)."

Our news editors obtained a quote from the research from the Pohang University of Science and Technology, "The cetyltrimethylammonium bromide bilayer on GNRs was replaced with heterobifunctional PEG (COOH-PEG-SH) not only to serve as a biocompatible stabilizer and but also to conjugate Apt(EGFR). Subsequently, to direct photothermal therapy agent toward epithelial cancer cells, the carboxylated PEGylated GNRs (PGNRs) were further functionalized with Apt(EGFR) using carbodiimide chemistry. Then, to assess the potential as biomarker-specific photothermal therapy agent of synthesized Apt(EGFR)-PGNRs, the optical properties, biocompatibility, colloidal stability, binding affinity, and epicellial cancer cell killing efficacy in vitro/in vivo under near-infrared laser irradiation were investigated."

According to the news editors, the research concluded: "As a result, Apt(EGFR)-PGNRs exhibit excellent tumor targeting ability and feasibility of effective photothermal ablation cancer therapy."

For more information on this research see: Aptamer-conjugated gold nanorod for photothermal ablation of epidermal growth factor receptor-overexpressed epithelial cancer. Journal of Biomedical Optics, 2014;19(5):22-27. Journal of Biomedical Optics can be contacted at: Spie-Soc Photo-Optical Instrumentation Engineers, 1000 20TH St, PO Box 10, Bellingham, WA 98225, USA (see also Membrane Proteins).

The news editors report that additional information may be obtained by contacting J. Choi, Pohang University of Science & Technology, POSTECH Aptamer Initiat, Div Integrat Biosci & Biotechnol, Pohang 790784, South Korea. Additional authors for this research include Y. Park, E.B. Choi, H.O. Kim, D.J. Kim, Y. Hong, S.H. Ryu, J.H. Lee, J.S. Suh, J. Yang, Y.M. Huh and S. Haam.

Keywords for this news article include: Asia, Pohang, Cancer, Therapy, Oncology, South Korea, Membrane Proteins, Peptide Receptors, Growth Factor Receptors

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC


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Source: Cancer Weekly


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