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Reports from University of Putra Malaysia Add New Data to Findings in Drug Delivery Systems (Characterization and In Vitro Sustained Release of...

August 6, 2014



Reports from University of Putra Malaysia Add New Data to Findings in Drug Delivery Systems (Characterization and In Vitro Sustained Release of Silibinin from pH Responsive Carbon Nanotube-Based Drug Delivery System)

By a News Reporter-Staff News Editor at Biotech Week -- Investigators publish new report on Drugs and Therapies. According to news reporting originating in Selangor, Malaysia, by NewsRx journalists, research stated, "The objective of the present study was to develop and characterize an in vitro sustained release formulation of silibinin (SB) using commercially available carboxylated multiwalled carbon nanotubes (COOH-MWCNTs) and to investigate cytotoxicity action of the synthesized nanohybrid (SB-MWCNTs). The resulting nanohybrid was characterized with Fourier transform infrared (FTIR), Raman spectroscopy, thermogravimetric analysis (TGA), ultraviolet-visible spectrophotometry (UV-Vis), scanning electron microscopy (SEM), and transmission electron microscopy (TEM)."

The news reporters obtained a quote from the research from the University of Putra Malaysia, "FTIR, Raman spectroscopy, and TGA analysis confirmed the adsorption of SB molecules to the COOH-MWCNTs. The release of SB from the COOH-MWCNTs nanocarrier was found to be sustained and pH-dependent. The maximum percentage release of SB from the nanocarrier reached approximately 96.6% and 43.1% within 1000 minutes when exposed to pH 7.4 and pH 4.8 solutions, respectively. It was observed that the release of kinetic behaviour of SB from the MWCNTs nanocarrier conformed well to pseudo-second order kinetic model. The obtained MTT result showed that the SB-MWCNTs exhibited enhanced cytotoxicity to human cancer cell lines in comparison with free SB at lower concentrations."

According to the news reporters, the research concluded: "These results suggest that SB-MWCNTs nanohybrid may be a promising nano drug delivery system with sustained release property for the treatment of cancers."

For more information on this research see: Characterization and In Vitro Sustained Release of Silibinin from pH Responsive Carbon Nanotube-Based Drug Delivery System. Journal of Nanomaterials, 2014;():1-10. Journal of Nanomaterials can be contacted at: Hindawi Publishing Corporation, 410 Park Avenue, 15TH Floor, #287 Pmb, New York, NY 10022, USA. (Hindawi Publishing - www.hindawi.com; Journal of Nanomaterials - www.hindawi.com/journals/jnm/)

Our news correspondents report that additional information may be obtained by contacting J.M. Tan, University of Putra Malaysia, Fac Med & Hlth Sci, Dept. of Human Anat, Serdang 43400, Selangor, Malaysia. Additional authors for this research include G. Karthivashan, P. Arulselvan, S. Fakurazi and M.Z. Hussein (see also Drugs and Therapies).

Keywords for this news article include: Asia, Selangor, Malaysia, Drugs and Therapies, Drug Delivery Systems

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC


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Source: Biotech Week


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