Reports from University of Notre Dame Add New Data to Findings in Liposomes (Liposomal Bortezomib Nanoparticles via Boronic Ester Prodrug Formulation for Improved Therapeutic Efficacy in Vivo)
By a News Reporter-Staff News Editor at Biotech Week -- Research findings on Biotechnology are discussed in a new report. According to news originating from Notre Dame, Indiana, by NewsRx correspondents, research stated, "In this study, we describe the development of liposomal bortezomib nanoparticles, which was accomplished by synthesizing bortezomib prodrugs with reversible boronic ester bonds and then incorporating the resulting prodrugs into the nanoparticles via surface conjugation. Initially, several prodrug candidates were screened based upon boronic ester stability using isobutylboronic acid as a model boronic acid compound."
Our news journalists obtained a quote from the research from the University of Notre Dame, "The two most stable candidates were then selected to create surface conjugated bortezomib prodrugs on the liposomes. Our strategy yielded stable liposomal bortezomib nanoparticles with a narrow size range of 100 nm and with high reproducibility. These liposomal bortezomib nanoparticles demonstrated significant proteasome inhibition and cytotoxicity against multiple myeloma cell lines in vitro and remarkable tumor growth inhibition with reduced systemic toxicity compared to free bortezomib in vivo."
According to the news editors, the research concluded: "Taken together, this study demonstrates the incorporation of bortezomib into liposomal nanoparticles via reversible boronic ester bond formation to enhance the therapeutic index for improved patient outcome."
For more information on this research see: Liposomal Bortezomib Nanoparticles via Boronic Ester Prodrug Formulation for Improved Therapeutic Efficacy in Vivo. Journal of Medicinal Chemistry, 2014;57(12):5282-5292. Journal of Medicinal Chemistry can be contacted at: Amer Chemical Soc, 1155 16TH St, NW, Washington, DC 20036, USA. (American Chemical Society - www.acs.org; Journal of Medicinal Chemistry - www.pubs.acs.org/journal/jmcmar)
The news correspondents report that additional information may be obtained from J.D. Ashley, University of Notre Dame, Dept. of Chem & Biochem, Notre Dame, IN 46556, United States. Additional authors for this research include J.F. Stefanick, V.A. Schroeder, M.A. Suckow, T. Kiziltepe and B. Bilgicer (see also Biotechnology).
Keywords for this news article include: Antineoplastics, Biotechnology, Pharmaceuticals, Drugs, Indiana, Therapy, Liposomes, Notre Dame, Bortezomib, Nanoparticle, United States, Nanotechnology, Emerging Technologies, North and Central America
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