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Recent Research from Chung Ang University Highlight Findings in Nanoparticles [Development of pH-responsive poly(gamma-cyclodextrin) derivative...

August 6, 2014

Recent Research from Chung Ang University Highlight Findings in Nanoparticles [Development of pH-responsive poly(gamma-cyclodextrin) derivative nanoparticles]

By a News Reporter-Staff News Editor at Biotech Week -- Investigators publish new report on Nanoparticles. According to news reporting out of Seoul, South Korea, by NewsRx editors, research stated, "In this study, we report a novel pH-responsive nanoparticle composed of poly(gamma-cyclodextrin) [poly(gamma CD)] conjugated with functional 3-diethylaminopropyl (DEAP) groups [poly(gamma CD-DEAP)]. The design of the nanoparticle takes advantage of the biocompatible functional poly(gamma CD) as the backbone polymer and the unique pH-responsive feature of DEAP as either a hydrophobic moiety (non-ionic DEAP) at pH 7.4 or a hydrophilic moiety (ionic DEAP) at acidic pH."

Our news journalists obtained a quote from the research from Chung Ang University, "Poly(gamma CD) was coupled with DEAP and utilized for fabricating pH-responsive nanoparticles for antitumor drug (doxorubicin: DOX) delivery. The experimental results reveal that the poly(gamma CD-DEAP) nanoparticles increased the release of the encapsulated DOX content when the pH of the solution was decreased to 6.0. This event caused significant increases in the efficiency of cellular DOX uptake and in vitro tumor inhibition."

According to the news editors, the research concluded: "Furthermore, these nanoparticles allow the encapsulation of multiple antitumor drugs into the nanoparticles [utilizing the hydrophobic interactions (between non-ionic DEAP moieties and drugs) and inclusive interactions (between poly(gamma CD)s and drugs)], thereby suggesting their potential for use in drug combination therapy."

For more information on this research see: Development of pH-responsive poly(gamma-cyclodextrin) derivative nanoparticles. Colloids and Surfaces B-Biointerfaces, 2014;119():14-21. Colloids and Surfaces B-Biointerfaces can be contacted at: Elsevier Science Bv, PO Box 211, 1000 Ae Amsterdam, Netherlands (see also Nanoparticles).

Our news journalists report that additional information may be obtained by contacting N.M. Oh, Chung Ang University, Coll Pharm, Seoul 155756, South Korea. Additional authors for this research include K.T. Oh and E.S. Lee.

Keywords for this news article include: Asia, Seoul, South Korea, Nanotechnology, Emerging Technologies

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC

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Source: Biotech Week

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