News Column

Patent Issued for Apparatus and Method for Treating a Regurgitant Heart Valve

August 4, 2014



By a News Reporter-Staff News Editor at Cardiovascular Week -- From Alexandria, Virginia, NewsRx journalists report that a patent by the inventor Navia, Jose L. (Shaker Heights, OH), filed on January 4, 2012, was published online on July 22, 2014 (see also The Cleveland Clinic Foundation).

The patent's assignee for patent number 8784483 is The Cleveland Clinic Foundation (Cleveland, OH).

News editors obtained the following quote from the background information supplied by the inventors: "The opening and closing of heart valves occur primarily as a result of pressure differences. For example, the opening and closing of the mitral valve occurs as a result of the pressure differences between the left atrium and the left ventricle. During ventricular diastole, the venous return of blood from the pulmonary veins into the left atrium causes the pressure in the atrium to exceed that in the left ventricle. As a result, the mitral valve opens and allows blood to enter the left ventricle. As the left ventricle contracts during ventricular systole, the intraventricular pressure rises above the pressure in the atrium and pushes the mitral valve shut.

"When the high pressure produced by contraction of the left ventricle pushes the valve leaflets too much, the leaflets become everted and prolapse results. This is normally prevented by contraction of the papillary muscles within the left ventricle, which are connected to the mitral valve leaflets by the chordae tendineae (chords). Contraction of the papillary muscles is simultaneous with the contraction of the left ventricle and serves to keep healthy mitral valve leaflets tightly shut at peak contraction pressures.

"Mitral valve malfunction can stem from a variety of etiologies. For example, the causes of mitral regurgitation can range from intrinsic disease of the leaflets (e.g., mainly due to degenerative disease in patients with mitral valve prolapse), to functional mitral regurgitation (FMR), in which the valve is anatomically normal but stretched due to tethering and annular dilatation. Although mitral regurgitation in intrinsic disease occurs initially as leaflet disease, secondary annular dilatation occurs in the large majority of patients by the time they present for treatment. The larger proportion of patients with mitral regurgitation includes those without intrinsic disease of the leaflets, i.e., FMR.

"Surgical correction of FMR is based upon overcorrection of concomitant annular dilatation using an undersized, complete, and rigid annuloplasty ring that is intended to reduce the diameter of the mitral annulus and allow for leaflet coaptation. Although complete correction of mitral regurgitation has been surgically demonstrated, an important recurrence of mitral regurgitation after annuloplasty valve repair is common (25%) because the left ventricle continues to dilate or remodel, thereby causing further tethering of the mitral leaflets."

As a supplement to the background information on this patent, NewsRx correspondents also obtained the inventor's summary information for this patent: "According to one aspect of the present invention, an apparatus is provided for treating regurgitation of blood flow through a diseased heart valve. The diseased heart valve includes an annulus, an anterior valve leaflet, and a posterior valve leaflet. The apparatus includes a substantially annular support member and at least one infra-annular support member securely connected thereto. The substantially annular support member has at least a first intermediate portion, a second intermediate portion, and a posterior end portion extending between the first and second intermediate portions. The posterior end portion is dimensioned for attachment to a posterior portion of the annulus of the diseased heart valve. The at least one infra-annular support member is securely connected to the substantially annular support member at a first location. The at least one infra-annular support member is dimensioned to extend below the posterior and anterior valve leaflets and across or behind at least one subvalvular structure.

"According to another aspect of the present invention, an apparatus is provided for treating regurgitation of blood flow through a diseased heart valve. The diseased heart valve includes an annulus, an anterior valve leaflet, and a posterior valve leaflet. The apparatus includes a substantially annular support member, a first infra-annular support member, and a second infra-annular support member. The substantially annular support member has at least a first intermediate portion, a second intermediate portion, and a posterior end portion extending between the first and second intermediate portions. The posterior end portion is dimensioned for attachment to a posterior portion of the annulus of the diseased heart valve. The first infra-annular support member is securely connected to the substantially annular support member at a first location. The second infra-annular support member is securely connected to the substantially annular support member at a second location. The first and second infra-annular support members are dimensioned to extend below at least one of the posterior and anterior valve leaflets and across or behind at least one subvalvular structure.

"According to another aspect of the present invention, a method is provided for treating regurgitation of blood flow through a diseased heart valve. The diseased heart valve includes an annulus, an anterior valve leaflet and a posterior valve leaflet. One step of the method includes providing an apparatus comprising a substantially annular support member and at least one infra-annular support member that is securely connected thereto. The substantially annular support member includes at least a first intermediate portion, a second intermediate portion, and a posterior end portion extending between the first and second intermediate portions. Next, the substantially annular support member is attached to the annulus of the diseased heart valve so that the at least one infra-annular support member extends below at least one of the posterior and anterior valve leaflets and across or behind at least one subvalvular structure to prevent or substantially reduce regurgitation of blood flow through the diseased heart valve."

For additional information on this patent, see: Navia, Jose L.. Apparatus and Method for Treating a Regurgitant Heart Valve. U.S. Patent Number 8784483, filed January 4, 2012, and published online on July 22, 2014. Patent URL: http://patft.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PALL&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.htm&r=1&f=G&l=50&s1=8784483.PN.&OS=PN/8784483RS=PN/8784483

Keywords for this news article include: Cardiology, The Cleveland Clinic Foundation.

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC


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Source: Cardiovascular Week


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