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New Vesicular Stomatitis Data Have Been Reported by Investigators at Boston University (Digital Sensing and Sizing of Vesicular Stomatitis Virus...

August 8, 2014



New Vesicular Stomatitis Data Have Been Reported by Investigators at Boston University (Digital Sensing and Sizing of Vesicular Stomatitis Virus Pseudotypes in Complex Media: A Model for Ebola and Marburg Detection)

By a News Reporter-Staff News Editor at Health & Medicine Week -- Current study results on Mouth Diseases and Conditions have been published. According to news reporting originating in Boston, Massachusetts, by NewsRx journalists, research stated, "Rapid, sensitive, and direct label-free capture and characterization of nanoparticles from complex media such as blood or serum will broadly impact medicine and the life sciences. We demonstrate identification of virus particles in complex samples for replication-competent wild-type vesicular stomatitis virus (VSV), defective VSV, and Ebola- and Marburg-pseudotyped VSV with high sensitivity and specificity."

The news reporters obtained a quote from the research from Boston University, "Size discrimination of the imaged nanoparticles (virions) allows differentiation between modified viruses having different genome lengths and facilitates a reduction in the counting of nonspecifically bound particles to achieve a limit-of-detection (LOD) of 5 x 10(3) pfu/mL for the Ebola and Marburg VSV pseudotypes. We demonstrate the simultaneous detection of multiple viruses in a single sample (composed of serum or whole blood) for screening applications and uncompromised detection capabilities in samples contaminated with high levels of bacteria. By employing affinity-based capture, size discrimination, and a 'digital' detection scheme to count single virus particles, we show that a robust and sensitive virus/nanoparticle sensing assay can be established for targets in complex samples."

According to the news reporters, the research concluded: "The nanoparticle microscopy system is termed the Single Particle Interferometric Reflectance Imaging Sensor (SP-IRIS) and is capable of high-throughput and rapid sizing of large numbers of biological nanoparticles on an antibody microarray for research and diagnostic applications."

For more information on this research see: Digital Sensing and Sizing of Vesicular Stomatitis Virus Pseudotypes in Complex Media: A Model for Ebola and Marburg Detection. ACS Nano, 2014;8(6):6047-6055. ACS Nano can be contacted at: Amer Chemical Soc, 1155 16TH St, NW, Washington, DC 20036, USA. (American Chemical Society - www.acs.org; ACS Nano - www.pubs.acs.org/journal/ancac3)

Our news correspondents report that additional information may be obtained by contacting G.G. Daaboul, Boston University, Photon Center, Boston, MA 02215, United States. Additional authors for this research include C.A. Lopez, J. Chinnala, B.B. Goldberg, J.H. Connor and M.S. Unlu (see also Mouth Diseases and Conditions).

Keywords for this news article include: Boston, Nanoparticle, Massachusetts, United States, Nanotechnology, Vesicular Stomatitis, Emerging Technologies, North and Central America, Mouth Diseases and Conditions

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC


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Source: Health & Medicine Week


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