New Tissue Engineering Data Have Been Reported by Investigators at Jilin University (Enhanced Biocompatibility of PLGA Nanofibers with Gelatin/Nano-Hydroxyapatite Bone Biomimetics Incorporation)
By a News Reporter-Staff News Editor at Biotech Week -- Fresh data on Biomedicine and Biomedical Engineering are presented in a new report. According to news reporting originating from Changchun, People's Republic of China, by NewsRx correspondents, research stated, "The biocompatibility of biomaterials is essentially for its application. The aim of current study was to evaluate the biocompatibility of poly(lactic-co-glycolic acid) (PLGA) /gelatin/nanohydroxyapatite (n-HA) (PGH) nano-fibers systemically to provide further rationales for the application of the composite electrospun fibers as a favorable platform for bone tissue engineering."
Our news editors obtained a quote from the research from Jilin University, "The PGH composite scaffold with diameter ranging from nano- to micrometers was fabricated by using electrospinning technique. Subsequently, we utilized confocal laser scanning microscopy (CLSM) and MTT assay to evaluate its cyto-compatibility in vitro. Besides, real-time quantitative polymerase chain reaction (qPCR) analysis and alizarin red staining (ARS) were performed to assess the osteoinductive activity. To further test in vivo, we implanted either PLGA or PGH composite scaffold in a rat subcutaneous model. The results demonstrated that PGH scaffold could better support osteoblasts adhesion, spreading, and proliferation and show better cyto-compatibility than pure PLGA scaffold. Besides, qPCR analysis and ARS showed that PGH composite scaffold exhibited higher osteoinductive activity owing to higher phenotypic expression of typical osteogenic genes and calcium deposition. The histology evaluation indicated that the incorporation of Gelatin/nanohydroxyapatite (GH) biomimetics could significantly reduce local inflammation."
According to the news editors, the research concluded: "Our data indicated that PGH composite electrospun nanofibers possessed excellent cytocompatibility, good osteogenic activity, as well as good performance of host tissue response, which could be versatile biocompatible scaffolds for bone tissue engineering."
For more information on this research see: Enhanced Biocompatibility of PLGA Nanofibers with Gelatin/Nano-Hydroxyapatite Bone Biomimetics Incorporation. ACS Applied Materials & Interfaces, 2014;6(12):9402-9410. ACS Applied Materials & Interfaces can be contacted at: Amer Chemical Soc, 1155 16TH St, NW, Washington, DC 20036, USA. (American Chemical Society - www.acs.org; ACS Applied Materials & Interfaces - www.pubs.acs.org/journal/aamick)
The news editors report that additional information may be obtained by contacting D.W. Li, Jilin University, State Key Lab Supramol Struct & Mat, Changchun 130012, People's Republic of China. Additional authors for this research include H.Z. Sun, L.M. Jiang, K. Zhang, W.D. Liu, Y. Zhu, J.Z. Fangteng, C. Shi, L. Zhao, H.C. Sun and B. Yang (see also Biomedicine and Biomedical Engineering).
Keywords for this news article include: Asia, Biomedicine and Biomedical Engineering, Gelatin, Changchun, Nanofiber, Biomimetics, Bone Research, Bioengineering, Scleroproteins, Bionanotechnology, Bone Regeneration, Nanobiotechnology, Emerging Technologies, Bone-Tissue Engineering, People's Republic of China
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