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New Synucleins Findings Reported from Lund University (A porous silicon immunoassay platform for fluorometric determination of alpha-synuclein in...

August 5, 2014



New Synucleins Findings Reported from Lund University (A porous silicon immunoassay platform for fluorometric determination of alpha-synuclein in human cerebrospinal fluid)

By a News Reporter-Staff News Editor at Life Science Weekly -- Research findings on Proteins are discussed in a new report. According to news reporting from Malmo, Sweden, by NewsRx journalists, research stated, "Levels of total and/or oligomeric alpha-synuclein may be used as a biomarker tool to aid in the diagnosis and development of new disease-modifying therapies. We report here on a porous silicon antibody microarray for the fluorimetric determination of cerebrospinal fluid levels of total alpha-synuclein, a protein involved the pathology of Parkinson's disease."

The news correspondents obtained a quote from the research from Lund University, "The surface of porous silicon has a 3-dimensional macro- and nanoporous structure, and this offers a large binding capacity for capturing probe molecules. Porous silicon also warrants efficient immobilization of antibodies by surface adsorption, and does not require chemical immobilization. The platform requires 10 mu L of cerebrospinal fluid, and each test requires 4 h for assay only (including immobilization of capturing antibody)."

According to the news reporters, the research concluded: "The limit of detection is 35 pg mL(-1) of alpha-synuclein in cerebrospinal fluid, and the dynamic analytical range extends from 0.01 to 100 ng center dot mL(-1)."

For more information on this research see: A porous silicon immunoassay platform for fluorometric determination of alpha-synuclein in human cerebrospinal fluid. Microchimica Acta, 2014;181(9-10):1143-1149. Microchimica Acta can be contacted at: Springer Wien, Sachsenplatz 4-6, PO Box 89, A-1201 Wien, Austria. (Springer - www.springer.com; Microchimica Acta - www.springerlink.com/content/0026-3672/)

Our news journalists report that additional information may be obtained by contacting S. Lee, Lund University, Dept. of Clin Sci Malmo, S-20502 Malmo, Sweden. Additional authors for this research include E. Silajdzic, H. Yang, M. Bjorkqvist, S. Kim, O.C. Jeong, O. Hansson and T. Laurell (see also Proteins).

Keywords for this news article include: Malmo, Sweden, Europe, Nanotechnology, Porous Silicon, alpha-Synuclein, Emerging Technologies, Nerve Tissue Proteins

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC


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Source: Life Science Weekly


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